Matches in SemOpenAlex for { <https://semopenalex.org/work/W1973858359> ?p ?o ?g. }
- W1973858359 endingPage "e0120221" @default.
- W1973858359 startingPage "e0120221" @default.
- W1973858359 abstract "The receptor for advanced glycation end products (RAGE) is a pattern-recognition receptor involved in neurodegenerative and inflammatory disorders. RAGE induces cellular signaling upon binding to a variety of ligands. Evidence suggests that RAGE up-regulation is involved in quinolinate (QUIN)-induced toxicity. We investigated the QUIN-induced toxic events associated with early noxious responses, which might be linked to signaling cascades leading to cell death. The extent of early cellular damage caused by this receptor in the rat striatum was characterized by image processing methods. To document the direct interaction between QUIN and RAGE, we determined the binding constant (Kb) of RAGE (VC1 domain) with QUIN through a fluorescence assay. We modeled possible binding sites of QUIN to the VC1 domain for both rat and human RAGE. QUIN was found to bind at multiple sites to the VC1 dimer, each leading to particular mechanistic scenarios for the signaling evoked by QUIN binding, some of which directly alter RAGE oligomerization. This work contributes to the understanding of the phenomenon of RAGE-QUIN recognition, leading to the modulation of RAGE function." @default.
- W1973858359 created "2016-06-24" @default.
- W1973858359 creator A5008530304 @default.
- W1973858359 creator A5008914465 @default.
- W1973858359 creator A5016993423 @default.
- W1973858359 creator A5017231817 @default.
- W1973858359 creator A5018076678 @default.
- W1973858359 creator A5020244809 @default.
- W1973858359 creator A5028772172 @default.
- W1973858359 creator A5029309407 @default.
- W1973858359 creator A5030980297 @default.
- W1973858359 creator A5031708635 @default.
- W1973858359 creator A5034147508 @default.
- W1973858359 creator A5038886277 @default.
- W1973858359 creator A5052542079 @default.
- W1973858359 creator A5066628512 @default.
- W1973858359 creator A5068682719 @default.
- W1973858359 date "2015-03-10" @default.
- W1973858359 modified "2023-10-18" @default.
- W1973858359 title "Modeling the Interaction between Quinolinate and the Receptor for Advanced Glycation End Products (RAGE): Relevance for Early Neuropathological Processes" @default.
- W1973858359 cites W1858816790 @default.
- W1973858359 cites W1929229765 @default.
- W1973858359 cites W1965011485 @default.
- W1973858359 cites W1966297486 @default.
- W1973858359 cites W1969383357 @default.
- W1973858359 cites W1979447111 @default.
- W1973858359 cites W1983952978 @default.
- W1973858359 cites W1984303089 @default.
- W1973858359 cites W1986585280 @default.
- W1973858359 cites W1996061474 @default.
- W1973858359 cites W1998037146 @default.
- W1973858359 cites W2003739799 @default.
- W1973858359 cites W2005869447 @default.
- W1973858359 cites W2008401426 @default.
- W1973858359 cites W2009498637 @default.
- W1973858359 cites W2013122439 @default.
- W1973858359 cites W2013730613 @default.
- W1973858359 cites W2015064865 @default.
- W1973858359 cites W2015253252 @default.
- W1973858359 cites W2016293448 @default.
- W1973858359 cites W2019654086 @default.
- W1973858359 cites W2024205788 @default.
- W1973858359 cites W2024356127 @default.
- W1973858359 cites W2027794695 @default.
- W1973858359 cites W2028143298 @default.
- W1973858359 cites W2028300397 @default.
- W1973858359 cites W2029667189 @default.
- W1973858359 cites W2034445899 @default.
- W1973858359 cites W2036408610 @default.
- W1973858359 cites W2037293198 @default.
- W1973858359 cites W2037312364 @default.
- W1973858359 cites W2041740456 @default.
- W1973858359 cites W2047284194 @default.
- W1973858359 cites W2048296320 @default.
- W1973858359 cites W2048700535 @default.
- W1973858359 cites W2050306625 @default.
- W1973858359 cites W2052340241 @default.
- W1973858359 cites W2057019886 @default.
- W1973858359 cites W2057844010 @default.
- W1973858359 cites W2060050678 @default.
- W1973858359 cites W2060619742 @default.
- W1973858359 cites W2060872117 @default.
- W1973858359 cites W2062545296 @default.
- W1973858359 cites W2064374752 @default.
- W1973858359 cites W2065158034 @default.
- W1973858359 cites W2071539925 @default.
- W1973858359 cites W2074473216 @default.
- W1973858359 cites W2075351997 @default.
- W1973858359 cites W2080133225 @default.
- W1973858359 cites W2081080245 @default.
- W1973858359 cites W2083519557 @default.
- W1973858359 cites W2092385384 @default.
- W1973858359 cites W2094628147 @default.
- W1973858359 cites W2100976048 @default.
- W1973858359 cites W2110994059 @default.
- W1973858359 cites W2113172296 @default.
- W1973858359 cites W2119656068 @default.
- W1973858359 cites W2127385733 @default.
- W1973858359 cites W2130479394 @default.
- W1973858359 cites W2130775443 @default.
- W1973858359 cites W2132262459 @default.
- W1973858359 cites W2132629607 @default.
- W1973858359 cites W2134967712 @default.
- W1973858359 cites W2137305986 @default.
- W1973858359 cites W2138953837 @default.
- W1973858359 cites W2142060886 @default.
- W1973858359 cites W2150981663 @default.
- W1973858359 cites W2155201844 @default.
- W1973858359 cites W2155702046 @default.
- W1973858359 cites W2163351331 @default.
- W1973858359 cites W2170688086 @default.
- W1973858359 cites W2403094776 @default.
- W1973858359 doi "https://doi.org/10.1371/journal.pone.0120221" @default.
- W1973858359 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4354912" @default.
- W1973858359 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/25757085" @default.
- W1973858359 hasPublicationYear "2015" @default.
- W1973858359 type Work @default.
- W1973858359 sameAs 1973858359 @default.