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- W1973860147 abstract "In gonadectomized rats of either sex s.c. administration of 5α-dihydrotestosterone (DHT) reversed, in a dose dependent manner, effects brought about by gonadectomy: it decreased pituitary wet weight and serum levels of LH and FSH and suppressed microsomal enzyme activities involved in testosterone and progesterone metabolism in the pituitary gland. NADPH-linked 5α-reductase and NADH-linked 3α-hydroxysteroid dehydrogenase (3α-HSDH). Concomitantly administered nonsteroidal antiandrogen, flutamide (5 mg/day), antagonized some of the suppressive effects induced by a 14-day treatment of gonadectomized rats with high dose (1 mg/day) of DHT. It completely blocked DHT action on pituitary 5α-reductase activity in the female rat and, in the male, inhibition was found to be 30–35%. In male, but not female rats, it completely blocked DHT suppression of serum FSH level whereas it slightly, but significantly inhibited DHT suppression of serum LH in rats of either sex. However, flutamide did not prevent DHT suppression of pituitary wet weight or NADH-linked 3α-HSDH activity. Concomitantly administered progestational antiandrogen, cyproterone acetate (5 mg/day), inhibited DHT-induced weight increase of seminal vesicles by 50–55% and completely blocked the weight decrease of pituitary gland but did not antagonize DHT suppression of serum gonadotropins or pituitary enzyme activities. The results obtained with flutamide suggest that DHT-induced suppression of pituitary NADPH-linked 5α-reductase, but not NADH-linked 3α-HSDH activity, might involve an androgen receptor mechanism." @default.
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- W1973860147 date "1982-04-01" @default.
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- W1973860147 title "The action of 5α-dihydrotestosterone and antiandrogens on the activities of 5α-reductase and 3α-hydroxysteroid dehydrogenase in the pituitary gland of gonadectomized rats" @default.
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- W1973860147 doi "https://doi.org/10.1016/0022-4731(82)90077-2" @default.
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