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- W1973878414 abstract "The appearance of the crystallins during lens development in the periodic albinism (ap/ap) mutant of Xenopus laevis has been studied. Using antibodies specific for total crystallins, α + β crystallins, and γ crystallins in the immunofluorescence technique, the first positive reaction for all could be demonstrated in the Nieuwkoop-Faber Stage 31 lens rudiment. The antibody to α + β crystallins exhibited differences in intensity from cell to cell in the early rudiment, while the reaction to the other antibodies was uniform throughout the rudiment. As lens differentiation progressed, immunofluorescence was restricted in all cases to the lens fiber area, up to and including Nieuwkoop-Faber Stage 45. The lens epithelium of the one-year-old adult ap/ap was positive, however, for total lens crystallins. These results are at variance with earlier studies on lens development and the crystallins in wild-type (+/+) X. laevis, where a positive reaction for y and total crystallins could be detected earlier, and in the lens epithelium of Nieuwkoop-Faber Stage 41 embryos for total lens crystallins. That this divergence in the mutant is due to a pleiotropic effect or directly to the inductive failure of the endomesoderm to initiate melanogenesis, is discussed." @default.
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- W1973878414 date "1979-09-01" @default.
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- W1973878414 title "Embryonic Appearance of α, β, and γ Crystallins in the Periodic Albinism (ap) Mutant of Xenopus laevis" @default.
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- W1973878414 doi "https://doi.org/10.1111/j.1432-0436.1979.tb01018.x" @default.
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