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- W1973889660 abstract "significantly correlated with androgen levels. At the consensus this measure was considered not easy for the routine practice. In order to verify the feasibility of this determination in the routine and to confirm the ability of S/A to predict hyperandrogenism in PCOS, we realized a multicenter study with 5 Italian groups. Subjects in fertile age, presenting oligomenorrhea or secondary amenorrhea, enlarged ovaries with > 10 cm3 and/or more than 12 follicles measuring 2–9 mm in diameter participated in the study. Transvaginal pelvic ultrasound was performed on each patient using a 6.5 MHz endovaginal probe The hormonal study included a baseline plasma determination of LH, FSH, Estradiol (E2), Androstenedione (A), Testosterone (T), Dehydroepiandrosteronesulphate (DHEAS), 17 hydroxyprogesterone (17-OHP), and Sex-hormone-binding globulin (SHBG). Receiver operator curves (ROC) were constructed to examine the diagnostic test performance, i.e., the ability to discriminate between subjects with normal or high androgen levels. The Youden indexes were calculated to find the significant S/A cutoff values in relation to A and T levels. The S/A resulted the better significant predictor for elevated A and T levels. The S/A cut-off identification obtained for both A and T indicate in 0.33 the best cut-off for the S/A ratio. This value could permit to identify the hyperandrogenic subjects by the US scan. In conclusion this work supports the importance of stroma evaluation in US diagnosis of PCOS." @default.
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- W1973889660 date "2006-08-31" @default.
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- W1973889660 title "OP21.01: Prospective internal evaluation of IOTA logistic regression model" @default.
- W1973889660 doi "https://doi.org/10.1002/uog.3369" @default.
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