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• W1973889679 abstract "Bone loss is a frequent complication after liver transplantation.To investigate whether vitamin D receptor gene polymorphism influences bone loss in men after liver transplantation.Prospective cohort study.University hospital.55 male candidates for liver transplantation.Lumbar spine bone mineral density was measured before and 3, 6, 12, and 24 months after liver transplantation. Vitamin D receptor genotype was determined by restriction endonuclease Bsml.Vitamin D receptor genotypes were significantly associated with post-transplantation changes in bone mineral density (P = 0.028). Within 3 months after transplantation, patients with the genotypes Bb or BB showed a vertebral bone loss substantially greater than that in patients with the bb genotype (between-group difference in the percentage change with respect to baseline bone mineral density, 3.7% [95% CI, 0.6% to 6.9%1). In 3 to 24 months after transplantation, bone mineral density increased steadily in the three allelic groups.Vitamin D receptor gene polymorphism influences bone loss after liver transplantation. Patients with the bb genotype are, to some extent, protected against post-transplantation bone loss." @default.
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• W1973889679 date "1999-11-16" @default.
• W1973889679 modified "2023-10-10" @default.
• W1973889679 title "Influence of the Vitamin D Receptor Gene Polymorphism on Bone Loss in Men after Liver Transplantation" @default.
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• W1973889679 doi "https://doi.org/10.7326/0003-4819-131-10-199911160-00006" @default.
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