FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1973897952> ?p ?o ?g. }

• W1973897952 endingPage "427" @default.
• W1973897952 startingPage "420" @default.
• W1973897952 abstract "Background During normal stratification of the epidermis, keratinocytes undergo a complex programme of terminal differentiation. This programmed cell death results in corneocyte accumulation to form the stratum corneum (SC). Terminal differentiation and apoptosis share numerous features such as elimination of nuclei and organelles, changes in cell shape, and activation of transglutaminases and proteases. Caspases are cysteine proteases that play a central role in apoptosis. Therefore they may also be involved in the terminal differentiation of keratinocytes. Objectives To identify the caspases expressed in normal human epidermis and to define their pattern of expression and activation. Methods We analysed mRNAs from human epidermis by reverse transcription–polymerase chain reaction (RT–PCR), skin cryosections by immunohistological methods, and epidermal protein extracts by Western blotting. Results The mRNAs encoding caspase‐1, ‐2, ‐3, ‐4, ‐6, ‐7, ‐8, ‐9, ‐10 and ‐14 were detected by RT–PCR. Accordingly, the immunohistological analyses showed clear expression in the epidermis of the corresponding proteins except caspase‐2 and caspase‐8, with only a weak expression of caspase‐9. Moreover, procaspase‐1, ‐2, ‐3, ‐4, ‐6, ‐7, ‐9, ‐10 and ‐14, and the fully processed caspase‐14, were immunodetected in total epidermis extracts. However, only procaspase‐1 and the processed caspase‐14 were detected in extracts of superficial SC. In addition to these two proteins, procaspase‐4 was detected in extracts of superficial SC obtained from lesional psoriatic skin. Conclusions This study, the first exhaustive description of caspase expression and processing in normal human epidermis, indicates that in vivo granular keratinocytes express nine procaspases, and in addition the activated form of caspase‐14. This confirms that only caspase‐14 is involved in keratinocyte differentiation, and suggests that keratinocytes are ready to induce apoptosis in response to cutaneous damage." @default.
• W1973897952 created "2016-06-24" @default.
• W1973897952 creator A5010784698 @default.
• W1973897952 creator A5018941888 @default.
• W1973897952 creator A5047719228 @default.
• W1973897952 creator A5060785743 @default.
• W1973897952 creator A5068806445 @default.
• W1973897952 creator A5085057122 @default.
• W1973897952 creator A5088825362 @default.
• W1973897952 date "2007-03-01" @default.
• W1973897952 modified "2023-10-03" @default.
• W1973897952 title "Nine procaspases are expressed in normal human epidermis, but only caspase-14 is fully processed" @default.
• W1973897952 cites W1547637047 @default.
• W1973897952 cites W1964272444 @default.
• W1973897952 cites W1966176339 @default.
• W1973897952 cites W1970843614 @default.
• W1973897952 cites W1977781495 @default.
• W1973897952 cites W1979154669 @default.
• W1973897952 cites W1979748640 @default.
• W1973897952 cites W1984028519 @default.
• W1973897952 cites W1984624243 @default.
• W1973897952 cites W1986331996 @default.
• W1973897952 cites W1989959258 @default.
• W1973897952 cites W1999906187 @default.
• W1973897952 cites W2000407232 @default.
• W1973897952 cites W2004962670 @default.
• W1973897952 cites W2007103248 @default.
• W1973897952 cites W2007766576 @default.
• W1973897952 cites W2007939817 @default.
• W1973897952 cites W2013888884 @default.
• W1973897952 cites W2021977295 @default.
• W1973897952 cites W2036339952 @default.
• W1973897952 cites W2042485805 @default.
• W1973897952 cites W2043902549 @default.
• W1973897952 cites W2044092032 @default.
• W1973897952 cites W2047183460 @default.
• W1973897952 cites W2048263113 @default.
• W1973897952 cites W2054578426 @default.
• W1973897952 cites W2055918882 @default.
• W1973897952 cites W2061380679 @default.
• W1973897952 cites W2065783672 @default.
• W1973897952 cites W2072502723 @default.
• W1973897952 cites W2072731476 @default.
• W1973897952 cites W2073960328 @default.
• W1973897952 cites W2080802208 @default.
• W1973897952 cites W2083753771 @default.
• W1973897952 cites W2083987291 @default.
• W1973897952 cites W2090702020 @default.
• W1973897952 cites W2092890100 @default.
• W1973897952 cites W2094338165 @default.
• W1973897952 cites W2116319477 @default.
• W1973897952 cites W2122851986 @default.
• W1973897952 cites W2125308703 @default.
• W1973897952 cites W2132852419 @default.
• W1973897952 cites W2140297626 @default.
• W1973897952 cites W2158714788 @default.
• W1973897952 cites W2315725883 @default.
• W1973897952 cites W2324111799 @default.
• W1973897952 cites W65867874 @default.
• W1973897952 doi "https://doi.org/10.1111/j.1365-2133.2006.07656.x" @default.
• W1973897952 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/17300228" @default.
• W1973897952 hasPublicationYear "2007" @default.
• W1973897952 type Work @default.
• W1973897952 sameAs 1973897952 @default.
• W1973897952 citedByCount "38" @default.
• W1973897952 countsByYear W19738979522012 @default.
• W1973897952 countsByYear W19738979522013 @default.
• W1973897952 countsByYear W19738979522014 @default.
• W1973897952 countsByYear W19738979522015 @default.
• W1973897952 countsByYear W19738979522016 @default.
• W1973897952 countsByYear W19738979522017 @default.
• W1973897952 countsByYear W19738979522020 @default.
• W1973897952 countsByYear W19738979522021 @default.
• W1973897952 countsByYear W19738979522022 @default.
• W1973897952 countsByYear W19738979522023 @default.
• W1973897952 crossrefType "journal-article" @default.
• W1973897952 hasAuthorship W1973897952A5010784698 @default.
• W1973897952 hasAuthorship W1973897952A5018941888 @default.
• W1973897952 hasAuthorship W1973897952A5047719228 @default.
• W1973897952 hasAuthorship W1973897952A5060785743 @default.
• W1973897952 hasAuthorship W1973897952A5068806445 @default.
• W1973897952 hasAuthorship W1973897952A5085057122 @default.
• W1973897952 hasAuthorship W1973897952A5088825362 @default.
• W1973897952 hasConcept C105702510 @default.
• W1973897952 hasConcept C12519072 @default.
• W1973897952 hasConcept C153911025 @default.
• W1973897952 hasConcept C179927520 @default.
• W1973897952 hasConcept C181199279 @default.
• W1973897952 hasConcept C182220744 @default.
• W1973897952 hasConcept C190283241 @default.
• W1973897952 hasConcept C202751555 @default.
• W1973897952 hasConcept C2776458125 @default.
• W1973897952 hasConcept C2777074287 @default.
• W1973897952 hasConcept C2778370115 @default.
• W1973897952 hasConcept C31573885 @default.
• W1973897952 hasConcept C54355233 @default.
• W1973897952 hasConcept C55493867 @default.
• W1973897952 hasConcept C86803240 @default.

• next