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- W1973921912 abstract "Background: Bronchial hyper-responsiveness in a military population has been evaluated by direct and indirect challenge methods. We hypothesized that negative methacholine challenge testing (MCT) was not sufficient to exclude significant bronchial hyper-responsiveness in a symptomatic military population with exertional dyspnea. The purpose of our study was to identify bronchial hyper-responsiveness in symptomatic military recruits and active duty personnel with normal baseline spirometry and negative pharmacologic bronchoprovocation testing. Methods: We performed a retrospective single center electronic chart review of symptomatic service members with a negative MCT who completed a subsequent exercise challenge test (ECT). Results: ECT was positive in 45 (26.4%) of 171 subjects (98 recruits). Subjects with a positive ECT had lower baseline forced expiratory volume in 1 second (FEV1), forced vital capacity (FVC) and FEV1/FVC than those with a negative ECT, and these differences were statistically significant. The mean drop in FEV1 with exercise challenge positive patients was 17.9 ± 9.2%, and the mean drop in FEV1 with MCT was significantly greater in exercise challenge positive patients (−9.5 ± 5.5 vs. −7.6 ± 5.5, p = 0.042). Exercise-induced bronchoconstriction (EIB) was observed in 41% of all recruits who subsequently did not complete training. Only 1 recruit subject of 28 with EIB completed training. Conclusions: Methacholine challenge is an insufficient screening test to detect bronchial hyper-responsiveness in a symptomatic military population. In military recruits, EIB is associated with training failure." @default.
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- W1973921912 date "2014-05-28" @default.
- W1973921912 modified "2023-10-04" @default.
- W1973921912 title "Methacholine challenge is insufficient to exclude bronchial hyper-responsiveness in a symptomatic military population" @default.
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- W1973921912 doi "https://doi.org/10.3109/02770903.2014.919003" @default.
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