Matches in SemOpenAlex for { <https://semopenalex.org/work/W1973938938> ?p ?o ?g. }
Showing items 1 to 66 of
66
with 100 items per page.
- W1973938938 endingPage "467" @default.
- W1973938938 startingPage "467" @default.
- W1973938938 abstract "Professor Lewis presents a collaborative trial adequately powered to assess the efficacy of sulodexide, an extractive glycosaminoglycan, in lowering microalbuminuria in patients with type 2 diabetes mellitus.1Lewis E.J. Lewis J.B. Green T. et al.Collaborative Study GroupSulodexide for kidney protection in type 2 diabetes mellitus with microalbuminuria: a randomized controlled trial.Am J Kidney Dis. 2011; 58: 729-736Abstract Full Text Full Text PDF PubMed Scopus (97) Google Scholar The results are negative; however, concomitant administration of angiotensin-converting enzyme inhibitors or angiotensin II receptor blockers “at the maximal approved dosage” left little allowance for a superimposed effect of sulodexide, or any other drug. The other sulodexide trial from the Collaborative Study Group, a study on severely macroalbuminuric patients,2Packham DK, Wolfe R, Reutens AT, et al; Collaborative Study Group. Sulodexide fails to demonstrate renoprotection in overt type 2 diabetic nephropathy [published online ahead of print October 27, 2011]. J Am Soc Nephrol. doi:10.1681/ASN/.2011040378.Google Scholar confronted sulodexide with an even more impossible task. The suspicion that sulodexide (the originator) may have no pharmacological activity whatsoever is unjustified. Provided the compound made available for this trial (the biosimilar drug) is equivalent to the originator, its absorption by the oral route, and clinical effects, have been demonstrated.3Coccheri S. Scondotto G. Agnelli G. et al.Sulodexide in the treatment of intermittent claudication Results of a randomized, double-blind, multicentre, placebo-controlled study.Eur Heart J. 2002; 23: 1057-1065Crossref PubMed Scopus (62) Google Scholar Recent studies suggest that sulodexide acts on the microvasculature in a manner not necessarily related to its activities as an antagonist of factor Xa and heparin cofactor II. The agent reduces proteinuria in early kidney injury4Rossini M. Naito T. Yang H. et al.Sulodexide ameliorates early but not late kidney disease in models of radiation nephropathy and diabetic nephropathy.Nephrol Dial Transplant. 2010; 25: 1803-1810Crossref PubMed Scopus (30) Google Scholar and should be tested in prevention of microvascular damage. Therefore, sulodexide maintains scientific and clinical interest and cannot be sentenced to “bite the dust”, as suggested by the editorial5House A.A. Weir M.A. Sulodexide for diabetic nephropathy: another one bites the dust.Am J Kidney Dis. 2011; 58: 692-694Abstract Full Text Full Text PDF PubMed Scopus (11) Google Scholar that accompanied the article by Lewis and colleagues. Financial Disclosure: The author declares consultancy relationships and/or honoraria for educational presentations, travel, and accommodation expenses from GlaxoSmithKline, Teofarma, Alfa-Wasserman (which manufactures sulodexide), and Federterme (the Italian federation of spa establishments) and its related research foundation, the Thermal Research Foundation. Sulodexide for Kidney Protection in Type 2 Diabetes Patients With Microalbuminuria: A Randomized Controlled TrialAmerican Journal of Kidney DiseasesVol. 58Issue 5PreviewSulodexide, a heterogenous group of sulfated glycosaminoglycans, includes low-molecular-weight heparin (∼80% ± 8%), high-molecular-weight heparin (∼5% ± 3%), and dermatan (∼20% ± 8%), with a mean molecular weight of ∼9 kDa. The drug is absorbed orally and has no anticoagulant effect in the doses used. Small preliminary studies consistently showed sulodexide to be associated with decreased albuminuria in patients with diabetes. Full-Text PDF" @default.
- W1973938938 created "2016-06-24" @default.
- W1973938938 creator A5055517858 @default.
- W1973938938 date "2012-03-01" @default.
- W1973938938 modified "2023-09-26" @default.
- W1973938938 title "Game Not Over for Sulodexide" @default.
- W1973938938 cites W1969528155 @default.
- W1973938938 cites W2011719351 @default.
- W1973938938 cites W2053435995 @default.
- W1973938938 cites W2120630138 @default.
- W1973938938 doi "https://doi.org/10.1053/j.ajkd.2011.12.010" @default.
- W1973938938 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/22340910" @default.
- W1973938938 hasPublicationYear "2012" @default.
- W1973938938 type Work @default.
- W1973938938 sameAs 1973938938 @default.
- W1973938938 citedByCount "5" @default.
- W1973938938 countsByYear W19739389382013 @default.
- W1973938938 countsByYear W19739389382015 @default.
- W1973938938 countsByYear W19739389382018 @default.
- W1973938938 countsByYear W19739389382019 @default.
- W1973938938 countsByYear W19739389382021 @default.
- W1973938938 crossrefType "journal-article" @default.
- W1973938938 hasAuthorship W1973938938A5055517858 @default.
- W1973938938 hasBestOaLocation W19739389381 @default.
- W1973938938 hasConcept C126322002 @default.
- W1973938938 hasConcept C134018914 @default.
- W1973938938 hasConcept C168563851 @default.
- W1973938938 hasConcept C2777180221 @default.
- W1973938938 hasConcept C2779922275 @default.
- W1973938938 hasConcept C2781184683 @default.
- W1973938938 hasConcept C2781203188 @default.
- W1973938938 hasConcept C555293320 @default.
- W1973938938 hasConcept C71924100 @default.
- W1973938938 hasConcept C98274493 @default.
- W1973938938 hasConceptScore W1973938938C126322002 @default.
- W1973938938 hasConceptScore W1973938938C134018914 @default.
- W1973938938 hasConceptScore W1973938938C168563851 @default.
- W1973938938 hasConceptScore W1973938938C2777180221 @default.
- W1973938938 hasConceptScore W1973938938C2779922275 @default.
- W1973938938 hasConceptScore W1973938938C2781184683 @default.
- W1973938938 hasConceptScore W1973938938C2781203188 @default.
- W1973938938 hasConceptScore W1973938938C555293320 @default.
- W1973938938 hasConceptScore W1973938938C71924100 @default.
- W1973938938 hasConceptScore W1973938938C98274493 @default.
- W1973938938 hasIssue "3" @default.
- W1973938938 hasLocation W19739389381 @default.
- W1973938938 hasLocation W19739389382 @default.
- W1973938938 hasOpenAccess W1973938938 @default.
- W1973938938 hasPrimaryLocation W19739389381 @default.
- W1973938938 hasRelatedWork W2038657938 @default.
- W1973938938 hasRelatedWork W2039838748 @default.
- W1973938938 hasRelatedWork W2105130711 @default.
- W1973938938 hasRelatedWork W2398404891 @default.
- W1973938938 hasRelatedWork W2414239003 @default.
- W1973938938 hasRelatedWork W2474822885 @default.
- W1973938938 hasRelatedWork W2945846550 @default.
- W1973938938 hasRelatedWork W3005682875 @default.
- W1973938938 hasRelatedWork W4319602501 @default.
- W1973938938 hasRelatedWork W87670072 @default.
- W1973938938 hasVolume "59" @default.
- W1973938938 isParatext "false" @default.
- W1973938938 isRetracted "false" @default.
- W1973938938 magId "1973938938" @default.
- W1973938938 workType "article" @default.