Matches in SemOpenAlex for { <https://semopenalex.org/work/W1973942079> ?p ?o ?g. }
Showing items 1 to 100 of
100
with 100 items per page.
- W1973942079 endingPage "968" @default.
- W1973942079 startingPage "961" @default.
- W1973942079 abstract "In the framework of a preliminary investigation on the plasma profile of cloxacillin after oral administration, a simple and rapid LC method was developed for the direct determination of this compound in human plasma. The on-line sample clean-up was carried out using a weak anion exchanger (diethylaminoethyl groups) as restricted access material (RAM). The effects of the washing liquid pH, the ionic strength and the addition of organic modifier to the washing liquid were studied in order to obtain an efficient sample clean-up and a high recovery of cloxacillin. The separation was achieved on octadecylsilica stationary phase using a mobile phase consisting in a mixture of phosphate buffer (pH 4.0; 25 mM) and acetonitrile (72:28, v/v). The UV detection was performed at 215 nm. The most appropriate regression model of the response function as well as the limit of quantitation (LOQ) were first selected during the pre-validation step. These criteria were then assessed during the formal validation step. The LOQ was 50 ng/ml. The method was also validated with respect to analyte recovery, precision, trueness, accuracy and linearity. Finally, it was successfully applied for the analysis of the first plasma samples obtained from patients having taken an oral dose of 500 mg cloxacillin." @default.
- W1973942079 created "2016-06-24" @default.
- W1973942079 creator A5001566376 @default.
- W1973942079 creator A5014292749 @default.
- W1973942079 creator A5038063185 @default.
- W1973942079 creator A5041202388 @default.
- W1973942079 creator A5058367563 @default.
- W1973942079 creator A5078249208 @default.
- W1973942079 date "2005-01-01" @default.
- W1973942079 modified "2023-09-25" @default.
- W1973942079 title "Development and validation of a fully automated LC method for the determination of cloxacillin in human plasma using anion exchange restricted access material for sample clean-up" @default.
- W1973942079 cites W1506981622 @default.
- W1973942079 cites W1968238151 @default.
- W1973942079 cites W1969147026 @default.
- W1973942079 cites W1976169140 @default.
- W1973942079 cites W1988233460 @default.
- W1973942079 cites W1996262571 @default.
- W1973942079 cites W2006998103 @default.
- W1973942079 cites W2011112210 @default.
- W1973942079 cites W2011464035 @default.
- W1973942079 cites W2012879773 @default.
- W1973942079 cites W2014968749 @default.
- W1973942079 cites W2031037077 @default.
- W1973942079 cites W2038085907 @default.
- W1973942079 cites W2039993350 @default.
- W1973942079 cites W2040506008 @default.
- W1973942079 cites W2046036839 @default.
- W1973942079 cites W2056427715 @default.
- W1973942079 cites W2071674427 @default.
- W1973942079 cites W2094408521 @default.
- W1973942079 cites W2094420656 @default.
- W1973942079 cites W2104291200 @default.
- W1973942079 cites W2128459738 @default.
- W1973942079 doi "https://doi.org/10.1016/j.jpba.2004.09.017" @default.
- W1973942079 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/15620520" @default.
- W1973942079 hasPublicationYear "2005" @default.
- W1973942079 type Work @default.
- W1973942079 sameAs 1973942079 @default.
- W1973942079 citedByCount "27" @default.
- W1973942079 countsByYear W19739420792012 @default.
- W1973942079 countsByYear W19739420792013 @default.
- W1973942079 countsByYear W19739420792015 @default.
- W1973942079 countsByYear W19739420792016 @default.
- W1973942079 countsByYear W19739420792017 @default.
- W1973942079 countsByYear W19739420792019 @default.
- W1973942079 crossrefType "journal-article" @default.
- W1973942079 hasAuthorship W1973942079A5001566376 @default.
- W1973942079 hasAuthorship W1973942079A5014292749 @default.
- W1973942079 hasAuthorship W1973942079A5038063185 @default.
- W1973942079 hasAuthorship W1973942079A5041202388 @default.
- W1973942079 hasAuthorship W1973942079A5058367563 @default.
- W1973942079 hasAuthorship W1973942079A5078249208 @default.
- W1973942079 hasConcept C10390740 @default.
- W1973942079 hasConcept C113196181 @default.
- W1973942079 hasConcept C117760992 @default.
- W1973942079 hasConcept C119128265 @default.
- W1973942079 hasConcept C145148216 @default.
- W1973942079 hasConcept C174802600 @default.
- W1973942079 hasConcept C178790620 @default.
- W1973942079 hasConcept C185592680 @default.
- W1973942079 hasConcept C2778576202 @default.
- W1973942079 hasConcept C2780408477 @default.
- W1973942079 hasConcept C43617362 @default.
- W1973942079 hasConcept C501593827 @default.
- W1973942079 hasConcept C55493867 @default.
- W1973942079 hasConceptScore W1973942079C10390740 @default.
- W1973942079 hasConceptScore W1973942079C113196181 @default.
- W1973942079 hasConceptScore W1973942079C117760992 @default.
- W1973942079 hasConceptScore W1973942079C119128265 @default.
- W1973942079 hasConceptScore W1973942079C145148216 @default.
- W1973942079 hasConceptScore W1973942079C174802600 @default.
- W1973942079 hasConceptScore W1973942079C178790620 @default.
- W1973942079 hasConceptScore W1973942079C185592680 @default.
- W1973942079 hasConceptScore W1973942079C2778576202 @default.
- W1973942079 hasConceptScore W1973942079C2780408477 @default.
- W1973942079 hasConceptScore W1973942079C43617362 @default.
- W1973942079 hasConceptScore W1973942079C501593827 @default.
- W1973942079 hasConceptScore W1973942079C55493867 @default.
- W1973942079 hasIssue "5" @default.
- W1973942079 hasLocation W19739420791 @default.
- W1973942079 hasLocation W19739420792 @default.
- W1973942079 hasOpenAccess W1973942079 @default.
- W1973942079 hasPrimaryLocation W19739420791 @default.
- W1973942079 hasRelatedWork W2044145238 @default.
- W1973942079 hasRelatedWork W2052368146 @default.
- W1973942079 hasRelatedWork W2076353278 @default.
- W1973942079 hasRelatedWork W2120891252 @default.
- W1973942079 hasRelatedWork W2137297405 @default.
- W1973942079 hasRelatedWork W2159789625 @default.
- W1973942079 hasRelatedWork W2320312871 @default.
- W1973942079 hasRelatedWork W2972588116 @default.
- W1973942079 hasRelatedWork W4286773617 @default.
- W1973942079 hasRelatedWork W4292466628 @default.
- W1973942079 hasVolume "36" @default.
- W1973942079 isParatext "false" @default.
- W1973942079 isRetracted "false" @default.
- W1973942079 magId "1973942079" @default.
- W1973942079 workType "article" @default.