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- W1973953669 abstract "The main objective of this study was to determine the intraocular concentration of fluorescein after applying five eye drops with only 1-min intervals in human eyes. The concentration of fluorescein in cornea and aqueous was studied with fluorophotometry in 11 healthy volunteers. Five 10-μl drops of 2% fluorescein solution were administered with 1-min intervals, and the intraocular concentrations that were achieved were compared with those obtained with just one eye drop. Five consecutive fluorescein drops caused a 2.6- to 3.1-fold increase in fluorescein concentrations of the anterior chamber 1–8 h after application compared with a single eye drop (p < 0.05). Corresponding values for the cornea were 2.1–2.8. As a conclusion, administration of five eye drops applied consecutively significantly increases intraocular drug concentration during 8 h in humans." @default.
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- W1973953669 date "1997-01-01" @default.
- W1973953669 modified "2023-09-28" @default.
- W1973953669 title "Effect of Consecutively Applied Fluorescein Eye Drops on Corneal and Aqueous Concentrations of Fluorescein" @default.
- W1973953669 doi "https://doi.org/10.1159/000267997" @default.
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