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- W1973954401 abstract "The effects of several calcium channel blockers (nifedipine, verapamil and diltiazem) on rat phrenic-hemidiaphragm preparations were studied. The calcium channel blockers were used either alone or associated with two aminoglycoside antibiotics, neomycin and streptomycin. All drugs investigated produced a concentration-dependent decrease in indirectly elicited diaphragmatic contractions. The order of potency was: verapamil greater than neomycin congruent to nifedipine greater than diltiazem greater than streptomycin. Moreover, neomycin-induced neuromuscular blockade was significantly increased by nifedipine (1 and 10 microM), verapamil (1 and 10 microM) and diltiazem (10 microM), whereas the streptomycin-induced neuromuscular blockade was increased only by nifedipine (1 and 10 microM) and verapamil (10 microM)." @default.
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- W1973954401 date "1986-08-01" @default.
- W1973954401 modified "2023-09-27" @default.
- W1973954401 title "Effects of calcium channel blockers on neuromuscular blockade induced by aminoglycoside antibiotics" @default.
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- W1973954401 doi "https://doi.org/10.1016/0014-2999(86)90556-x" @default.
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