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• W1973960007 abstract "A Coulter Counter Model TAII was used to study the effect of particle size on the initial surface-specific dissolution rates of some fine particulate, sparingly soluble drugs. For all the materials studied, the surface-specific dissolution rate and the ratios of this value to the equilibrium solubility, increased with a decrease in particle size. This was especially pronounced when the particle size was below approximately 5 μm. No significant effect of agitation intensity on surface-specific dissolution rate was recorded for the finest particles while higher values were obtained for the coarser fractions when the agitation intensity was increased. The results were explained by a reduction in the diffusion boundary layer thickness with the decrease in particle size." @default.
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• W1973960007 date "1988-11-01" @default.
• W1973960007 modified "2023-09-24" @default.
• W1973960007 title "Physicochemical aspects of drug release. VIII. The relation between particle size and surface specific dissolution rate in agitated suspensions" @default.
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• W1973960007 doi "https://doi.org/10.1016/0378-5173(88)90235-9" @default.
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