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- W1973967584 abstract "Skin window (SW) tests were performed in ten HIV1-infected patients and in ten healthy volunteers. The chemotaxis of monocytes/macrophages is weakened in AIDS patients, since the number of monocytes/macrophages attracted by the SW stimulus decreases in HIV1-infected subjects during the observation time, whereas the number increases in control individuals. HLA-DR expression decreases faster in AIDS patients than in healthy volunteers. Giant cell formation occurs and disappears earlier in HIV1-infected patients than in healthy control individuals. The results suggest that, at least in part, the impairment of chemotaxis and other functional abnormalities of mononuclear phagocytes are caused by their accelerated aging in HIV1-infected patients. Des ⪡fenêtres cutanées⪢ ont été réalisées chez 10 sujets infectés par le VIH1 et chez 10 volontaires sains. La chimiotaxie des monocytes/macrophages (MM) est affaiblie chez des malades atteints de SIDA puisque le nombre de MM, attirés par le stimulus de la fenêtre cutanée, diminue chez les sujets infectés par le VIH1, durant le temps de l'observation, alors que le nombre augmente chez les témoins. L'expression HLA-DR diminue plus vite chez les malades atteints de SIDA que chez les volontaires sains. La formation de cellules géantes se produit et disparaît plus tôt chez les sujets infectés par le VIH1 que chez les t'emoins. Les résultats suggérent que, en partie au moins, l'alteration de la chimiotaxie et les autres anomalies fonctionnelles des phagocytes mononucléés sont provoqués par le vieillissement accéléré chez les sujets infectés par le VIH1." @default.
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- W1973967584 date "1990-03-01" @default.
- W1973967584 modified "2023-10-13" @default.
- W1973967584 title "Functional abnormalities of monocytes/macrophages in HIV1-infected patients as demonstrated by the skin window procedure" @default.
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- W1973967584 doi "https://doi.org/10.1016/0923-2516(90)90027-g" @default.
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