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- W1973975463 endingPage "596" @default.
- W1973975463 startingPage "587" @default.
- W1973975463 abstract "Addictions to cocaine or heroin/prescription opioids [short-acting μ-opioid receptor (MOPr) agonists] involve relapsing cycles, with experimentation/escalating use, withdrawal/abstinence, and relapse/re-escalation. κ-Opioid receptors (KOPr; encoded by OPRK1), and their endogenous agonists, the dynorphins (encoded by PDYN), have counter-modulatory effects on reward caused by cocaine or MOPr agonist exposure, and exhibit plasticity in addictive-like states. KOPr/dynorphin activation is implicated in depression/anxiety, often comorbid with addictions. In this opinion article we propose that particular stages of the addiction cycle are differentially affected by KOPr/dynorphin systems. Vulnerability and resilience can be due to pre-existing (e.g., genetic) factors, or epigenetic modifications of the OPRK1 or PDYN genes during the addiction cycle. Pharmacotherapeutic approaches limiting changes in KOPr/dynorphin tone, especially with KOPr partial agonists, may hold potential for the treatment of specific drug addictions and psychiatric comorbidity." @default.
- W1973975463 created "2016-06-24" @default.
- W1973975463 creator A5039487284 @default.
- W1973975463 creator A5083171935 @default.
- W1973975463 creator A5088904673 @default.
- W1973975463 date "2012-10-01" @default.
- W1973975463 modified "2023-09-25" @default.
- W1973975463 title "κ-opioid receptor/dynorphin system: genetic and pharmacotherapeutic implications for addiction" @default.
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