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• W1973982011 abstract "La neoplasia intraepitelial prostática de alto grado (PIN-AG) y el foco de microglándulas atípicas (ASAP) son dos hallazgos histológicos estrechamente relacionados con el cáncer de próstata. En este trabajo se analiza una serie amplia de ambos diagnósticos como único dato reseñable en la primera biopsia y su relación con el adenocarcinoma de próstata aparecido en biopsias subsiguientes.Se analizan histológicamente 125 PIN-AG sin adenocarcinoma concomitante y 45 ASAP diagnosticados entre un total de 4.770 biopsias transrectales durante un periodo de 8 años (1998-2005). Se analizan todas las rebiopsias de cada uno de los casos y las características propias de los carcinomas aparecidos en algunas de éstas.El porcentaje de cáncer en la muestra general es del 30,3%. Sin embargo, entre los casos previamente diagnosticados de PIN-AG se detectó cáncer en 21 (16,8%) y entre los diagnosticados de ASAP, en 12 (26,7%). La demora media entre ambos diagnósticos y el cáncer fue de 12,3 y 12,7 meses, respectivamente. El número de rebiopsias necesarias hasta la aparición de cáncer fue de 1 a 4 en el PIN-AG y de 1 a 3 en el ASAP. Se observa una correlación significativa entre el PIN-AG y varios parámetros histológicos del cáncer en la biopsia [número de focos de cáncer (p=0,003), milímetros totales de cáncer (p=0,000), bilateralidad (p=0,024), Índice de Gleason (p=0,011), invasión perineural (p=0,015)] y en la prostatectomía radical [pT (p=0,010)].No existe mayor probabilidad de detectar cáncer de próstata en aquellos pacientes con diagnóstico previo de PIN-AG o ASAP respecto de la población general que se biopsia. En el caso de existir cáncer, pueden ser necesarias hasta 4 biopsias repetidas para detectarlo.High-grade PIN and ASAP are histological findings closely related to prostate cancer. We analyse a large series of both diagnoses and their relationship with the prostate cancers appeared in subsequent biopsies.We analyse 125 high-grade PIN and 45 ASAP cases diagnosed among 4,770 transrectal biopsies during an 8-year period (1998-2005). The histological characteristics of all the rebiopsies and the peculiarities of every cancer subsequently diagnosed of cancer are reviewed.Prostate cancer was detected in 30.3% in the general series. However, it was found only in 16.8% and 26.7% of cases previously diagnosed as high grade PIN and ASAP, respectively. Mean delay in the diagnosis of cancer was 12.3 and 12.7 months and the number of rebiopsies needed for it oscillated between 1and 4 in high-grade PIN and 1 and 3 in ASAP. A significant correlation between high-grade PIN and several histological parameters of cancer in the biopsy [number of cancer foci (p=0.003), total millimetres of cancer (p=0.000), bilateralism (p=0.024), Gleason index (p=0.011), perineurial invasion (p=0.015)] and in the radical prostatectomy [pT (p=0.010)] were detected.There is no higher probability to found prostate cancer in cases with previous high-grade PIN or ASAP. The diagnosis of cancer may need up to 4 repeated biopsies." @default.
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• W1973982011 date "2009-03-01" @default.
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• W1973982011 title "936 TARGETED NEEDLE RE-BIOPSY OF THE PROSTATE AFTER COMBINATION OF ENDORECTAL MRI (ENDOMRI) AND MAGNETIC RESONANCE SPECTROSCOPY (MRS) IN PATIENTS WITH ATYPICAL SMALL ACINAR PROLIFERATION (ASAP)" @default.
• W1973982011 doi "https://doi.org/10.1016/s1569-9056(09)60921-0" @default.
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