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• W1973984997 abstract "The hydroxylase encoded by the ptlH (SAV2991) gene from the pentalenolactone gene cluster of Streptomyces avermitilis was cloned by PCR and expressed in Escherichia coli as an N-terminal His6-tag protein. Incubation of recombinant PtlH with (+/-)-1-deoxypentalenic acid (5) in the presence of Fe(II), alpha-ketoglutarate, and O2 gave (-)-11beta-hydroxy-1-deoxypentalenic acid (8), whose structure and stereochemistry were determined by a combination of 1H, 13C, COSY, HMQC, HMBC, and NOESY NMR. The steady-state kinetic parameters were kcat = 4.2 +/- 0.6 s-1 and Km (5) = 0.57 +/- 0.19 mM. 8 is a new intermediate in the conversion of the sesquiterpene pentalenene (3) to pentalenolactone (1)." @default.
• W1973984997 created "2016-06-24" @default.
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• W1973984997 date "2006-04-29" @default.
• W1973984997 modified "2023-10-18" @default.
• W1973984997 title "Pentalenolactone Biosynthesis. Molecular Cloning and Assignment of Biochemical Function to PtlH, A Non-Heme Iron Dioxygenase of <i>Streptomyces </i><i>avermitilis</i>" @default.
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• W1973984997 doi "https://doi.org/10.1021/ja061469i" @default.
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