Matches in SemOpenAlex for { <https://semopenalex.org/work/W1973992005> ?p ?o ?g. }
Showing items 1 to 84 of
84
with 100 items per page.
- W1973992005 endingPage "15882" @default.
- W1973992005 startingPage "15876" @default.
- W1973992005 abstract "ATP interaction with lens alpha-crystallins leading to enhanced chaperone activity is not yet well understood. One model for chaperone activity of small heat shock proteins proposes that ATP causes small heat shock proteins to release substrates, which are then renatured by other larger heat shock proteins. A similar role has been proposed for ATP in alpha-crystallin chaperone activity. To evaluate this model, ATP-induced structural changes of native human alpha-crystallin assemblies were determined by hydrogen-deuterium exchange. In these experiments, hydrogen-deuterium exchange, measured by mass spectrometry, gave direct evidence that ATP decreases the accessibility of amide hydrogens in multiple regions of both alphaA and alphaB. The surface encompassed by these regions is much larger than would be shielded by a single ATP, implying that multiple ATP molecules bind to each subunit and/or ATP causes a more compact alpha-crystallin structure. Such a conformational change could release a bound substrate. The regions most affected by ATP are near putative substrate binding regions of alphaA and alphaB and in the C-terminal extension of alphaB. The widespread decrease in hydrogen-deuterium exchange with particularly large decreases near substrate binding regions suggests that ATP releases substrates via both direct displacement and a global conformational change." @default.
- W1973992005 created "2016-06-24" @default.
- W1973992005 creator A5013536327 @default.
- W1973992005 creator A5038705255 @default.
- W1973992005 creator A5083508577 @default.
- W1973992005 date "2002-12-01" @default.
- W1973992005 modified "2023-09-25" @default.
- W1973992005 title "α-Crystallin Regions Affected by Adenosine 5‘-Triphosphate Identified by Hydrogen−Deuterium Exchange" @default.
- W1973992005 cites W1537274817 @default.
- W1973992005 cites W1645482826 @default.
- W1973992005 cites W1671787304 @default.
- W1973992005 cites W2018084854 @default.
- W1973992005 cites W2021686435 @default.
- W1973992005 cites W2022704362 @default.
- W1973992005 cites W2038029551 @default.
- W1973992005 cites W2052073382 @default.
- W1973992005 cites W2079268821 @default.
- W1973992005 cites W2081026737 @default.
- W1973992005 doi "https://doi.org/10.1021/bi026568x" @default.
- W1973992005 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/12501218" @default.
- W1973992005 hasPublicationYear "2002" @default.
- W1973992005 type Work @default.
- W1973992005 sameAs 1973992005 @default.
- W1973992005 citedByCount "14" @default.
- W1973992005 countsByYear W19739920052013 @default.
- W1973992005 countsByYear W19739920052015 @default.
- W1973992005 countsByYear W19739920052017 @default.
- W1973992005 countsByYear W19739920052021 @default.
- W1973992005 crossrefType "journal-article" @default.
- W1973992005 hasAuthorship W1973992005A5013536327 @default.
- W1973992005 hasAuthorship W1973992005A5038705255 @default.
- W1973992005 hasAuthorship W1973992005A5083508577 @default.
- W1973992005 hasConcept C104292427 @default.
- W1973992005 hasConcept C104317684 @default.
- W1973992005 hasConcept C12554922 @default.
- W1973992005 hasConcept C142724271 @default.
- W1973992005 hasConcept C167569220 @default.
- W1973992005 hasConcept C178790620 @default.
- W1973992005 hasConcept C185592680 @default.
- W1973992005 hasConcept C2775962898 @default.
- W1973992005 hasConcept C2779564974 @default.
- W1973992005 hasConcept C512968161 @default.
- W1973992005 hasConcept C55493867 @default.
- W1973992005 hasConcept C71240020 @default.
- W1973992005 hasConcept C71924100 @default.
- W1973992005 hasConcept C8010536 @default.
- W1973992005 hasConcept C86803240 @default.
- W1973992005 hasConceptScore W1973992005C104292427 @default.
- W1973992005 hasConceptScore W1973992005C104317684 @default.
- W1973992005 hasConceptScore W1973992005C12554922 @default.
- W1973992005 hasConceptScore W1973992005C142724271 @default.
- W1973992005 hasConceptScore W1973992005C167569220 @default.
- W1973992005 hasConceptScore W1973992005C178790620 @default.
- W1973992005 hasConceptScore W1973992005C185592680 @default.
- W1973992005 hasConceptScore W1973992005C2775962898 @default.
- W1973992005 hasConceptScore W1973992005C2779564974 @default.
- W1973992005 hasConceptScore W1973992005C512968161 @default.
- W1973992005 hasConceptScore W1973992005C55493867 @default.
- W1973992005 hasConceptScore W1973992005C71240020 @default.
- W1973992005 hasConceptScore W1973992005C71924100 @default.
- W1973992005 hasConceptScore W1973992005C8010536 @default.
- W1973992005 hasConceptScore W1973992005C86803240 @default.
- W1973992005 hasIssue "52" @default.
- W1973992005 hasLocation W19739920051 @default.
- W1973992005 hasLocation W19739920052 @default.
- W1973992005 hasOpenAccess W1973992005 @default.
- W1973992005 hasPrimaryLocation W19739920051 @default.
- W1973992005 hasRelatedWork W1973992005 @default.
- W1973992005 hasRelatedWork W2020557128 @default.
- W1973992005 hasRelatedWork W2060700064 @default.
- W1973992005 hasRelatedWork W2063327837 @default.
- W1973992005 hasRelatedWork W2077917074 @default.
- W1973992005 hasRelatedWork W2107851838 @default.
- W1973992005 hasRelatedWork W2922407871 @default.
- W1973992005 hasRelatedWork W2942002361 @default.
- W1973992005 hasRelatedWork W3106024955 @default.
- W1973992005 hasRelatedWork W4210465013 @default.
- W1973992005 hasVolume "41" @default.
- W1973992005 isParatext "false" @default.
- W1973992005 isRetracted "false" @default.
- W1973992005 magId "1973992005" @default.
- W1973992005 workType "article" @default.