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- W1973996075 abstract "Ro41-0960 (3,4-dihydroxy-5-nitro-2′-fluorobenzophenone) is a potent, fluorine containing COMT inhibitor. In order to map catechol-O-methyltransferase (COMT) in vivo with PET, no-carrier-added [18F]Ro41-0960 was synthesized by the nucleophilic aromatic substitution of [18F]fluoride for 2′-nitro on 3,4-dimethoxy-5,2′-dinitrobenzophenone, followed by hydrolysis with HBr. During the course of this study it was found that [18F]fluoromethane ([18F]CH3F) was generated as the side product of nucleophilic aromatic substitution reaction. Various precursors with different hydroxyl protecting groups were then investigated for the effects on this side reaction. © 1997 John Wiley & Sons, Ltd." @default.
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- W1973996075 date "1997-04-01" @default.
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- W1973996075 title "Synthesis of [18F]Ro41-0960, a potent catechol-O-methyltransferase inhibitor, for PET studies" @default.
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- W1973996075 doi "https://doi.org/10.1002/(sici)1099-1344(199704)39:4<303::aid-jlcr977>3.0.co;2-w" @default.
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