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• W1974003669 abstract "Traditionally, tumors are classified by histopathological criteria, i.e., based on their specific morphological appearances. Consequently, current therapeutic decisions in oncology are strongly influenced by histology rather than underlying molecular or genomic aberrations. The increase of information on molecular changes however, enabled by the Human Genome Project and the International Cancer Genome Consortium as well as the manifold advances in molecular biology and high-throughput sequencing techniques, inaugurated the integration of genomic information into disease classification. Furthermore, in some cases it became evident that former classifications needed major revision and adaption. Such adaptations are often required by understanding the pathogenesis of a disease from a specific molecular alteration, using this molecular driver for targeted and highly effective therapies. Altogether, reclassifications should lead to higher information content of the underlying diagnoses, reflecting their molecular pathogenesis and resulting in optimized and individual therapeutic decisions. The objective of this article is to summarize some particularly important examples of genome-based classification approaches and associated therapeutic concepts. In addition to reviewing disease specific markers, we focus on potentially therapeutic or predictive markers and the relevance of molecular diagnostics in disease monitoring." @default.
• W1974003669 created "2016-06-24" @default.
• W1974003669 creator A5050531795 @default.
• W1974003669 creator A5066376775 @default.
• W1974003669 date "2014-05-28" @default.
• W1974003669 modified "2023-09-24" @default.
• W1974003669 title "Changing Histopathological Diagnostics by Genome-Based Tumor Classification" @default.
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• W1974003669 doi "https://doi.org/10.3390/genes5020444" @default.
• W1974003669 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4094942" @default.
• W1974003669 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/24879454" @default.
• W1974003669 hasPublicationYear "2014" @default.
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