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- W1974007095 abstract "A theoretical model has been developed to relate passive diffusional transport with a parameter termed the lipophilic-eutectic coefficient, L c . Based on this parameter it is proposed that the lipophilicity of a substance can be estimated. The method is based on the melting point lowering of a pure substance in the presence of an impurity of similar structure. Cholesterol was chosen as a model biological lipid because it is a neutral lipid that is found in relatively high concentrations in a variety of membranes. Transdermal absorption in humans and intestinal absorption in the rat both show a high degree of correlation with respect to L c . For our studies, L c appears to be as satisfactory as the partition coefficient for estimating lipophilicity and its determination is less demanding analytically." @default.
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- W1974007095 date "1986-12-01" @default.
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- W1974007095 title "A relationship between diffusional transport in lipid membranes and a lipophilic-eutectic parameter" @default.
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- W1974007095 doi "https://doi.org/10.1016/s0022-5193(86)80251-x" @default.
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