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- W1974010229 abstract "Bone marrow mesenchymal stromal/stem cell (MSC) encapsulation within a biomatrix could improve cellular delivery and extend survival and residence time over conventional intravenous administration. Although MSCs modulate monocyte/macrophage (Mø) immunophenotypic properties, little is known about how such interactions are influenced when MSCs are entrapped within a biomaterial. Furthermore, the impact of the cell-encapsulating matrix on MSC multipotency and on Møs, which infiltrate biomaterials, remains poorly understood. Here we elucidate this three-way interaction. The Mø immunophenotype and MSC differentiation were examined with regard to established and experimental collagen-based biomaterials for MSC entrapment. Tumor necrosis factor-α secretion was acutely inhibited at 4 days. MSCs cocultured with Møs demonstrated attenuated chondrocyte differentiation, whereas osteoblast differentiation was enhanced. Adipocyte differentiation was considerably enhanced for MSCs entrapped within the gelatin/polyethylene glycol-based matrix. A better understanding of the effect of cell encapsulation on differentiation potency and immunomodulation of MSCs is essential for MSC-based, biomaterial-enabled therapies." @default.
- W1974010229 created "2016-06-24" @default.
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- W1974010229 creator A5040185213 @default.
- W1974010229 creator A5079819848 @default.
- W1974010229 date "2012-10-01" @default.
- W1974010229 modified "2023-10-18" @default.
- W1974010229 title "Cell Encapsulating Biomaterial Regulates Mesenchymal Stromal/Stem Cell Differentiation and Macrophage Immunophenotype" @default.
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- W1974010229 doi "https://doi.org/10.5966/sctm.2012-0061" @default.
- W1974010229 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3659655" @default.
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