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- W1974016811 endingPage "587" @default.
- W1974016811 startingPage "576" @default.
- W1974016811 abstract "Systemic candidiasis is a significant cause of nosocomial infections and the mechanisms of defense against Candida albicans in humans remain poorly understood. Studies in animal models have demonstrated the importance of innate immunity in controlling the response to infection. Although Th1 cytokines have been shown to direct the overall outcome of infection, the precise role of the Th1/Th2 response and, more generally, the adaptive immune response as a whole, in systemic candidiasis, appears to apply mainly to the development of resistance to reinfection. A genetic approach to the identification of host factors regulating pathogenesis and susceptibility to C. albicans infection has been used in humans and in mouse models of infection. Mouse mutants bearing experimentally induced mutations in specific genes have provided a systematic tool for directly assessing the role of individual proteins in C. albicans susceptibility. Inbred mouse strains have been valuable in showcasing the spectrum of naturally occurring variations in initial susceptibility to infection, and type of disease developed. Crosses between resistant and susceptible strains have led to the detection of additional gene effects affecting innate immunity. Of particular interest is the major effect of a naturally occurring loss-of-function mutation in the C5 complement component that has become fixed in many inbred strains. These and other studies have shown that both a functional complement pathway and robust inflammatory response are critical for resistance to C. albicans." @default.
- W1974016811 created "2016-06-24" @default.
- W1974016811 creator A5032658444 @default.
- W1974016811 creator A5045348393 @default.
- W1974016811 creator A5078127601 @default.
- W1974016811 date "2004-09-16" @default.
- W1974016811 modified "2023-09-27" @default.
- W1974016811 title "Genetic analysis of innate immunity in resistance to Candida albicans" @default.
- W1974016811 cites W12754177 @default.
- W1974016811 cites W1495915055 @default.
- W1974016811 cites W1499921224 @default.
- W1974016811 cites W1517386827 @default.
- W1974016811 cites W1519886765 @default.
- W1974016811 cites W1520075377 @default.
- W1974016811 cites W1547948326 @default.
- W1974016811 cites W1573307145 @default.
- W1974016811 cites W1627009127 @default.
- W1974016811 cites W1654658858 @default.
- W1974016811 cites W1666861259 @default.
- W1974016811 cites W1825031497 @default.
- W1974016811 cites W1831371755 @default.
- W1974016811 cites W1852089397 @default.
- W1974016811 cites W1859805933 @default.
- W1974016811 cites W1873750518 @default.
- W1974016811 cites W1874479041 @default.
- W1974016811 cites W1899544836 @default.
- W1974016811 cites W1934712179 @default.
- W1974016811 cites W1964473760 @default.
- W1974016811 cites W1965368723 @default.
- W1974016811 cites W1965897811 @default.
- W1974016811 cites W1966386267 @default.
- W1974016811 cites W1968128503 @default.
- W1974016811 cites W1972224178 @default.
- W1974016811 cites W1978878058 @default.
- W1974016811 cites W1979094847 @default.
- W1974016811 cites W1983183777 @default.
- W1974016811 cites W1986506708 @default.
- W1974016811 cites W1987277594 @default.
- W1974016811 cites W2004260015 @default.
- W1974016811 cites W2004773897 @default.
- W1974016811 cites W2006862282 @default.
- W1974016811 cites W2014061201 @default.
- W1974016811 cites W2015361718 @default.
- W1974016811 cites W2017284605 @default.
- W1974016811 cites W2022022413 @default.
- W1974016811 cites W2024242455 @default.
- W1974016811 cites W2028222510 @default.
- W1974016811 cites W2028395236 @default.
- W1974016811 cites W2034345422 @default.
- W1974016811 cites W2038521929 @default.
- W1974016811 cites W2047935185 @default.
- W1974016811 cites W2048411015 @default.
- W1974016811 cites W2049771668 @default.
- W1974016811 cites W2049868373 @default.
- W1974016811 cites W2051818630 @default.
- W1974016811 cites W2054164850 @default.
- W1974016811 cites W2055960613 @default.
- W1974016811 cites W2060726557 @default.
- W1974016811 cites W2069703720 @default.
- W1974016811 cites W2071336102 @default.
- W1974016811 cites W2075579211 @default.
- W1974016811 cites W2082370749 @default.
- W1974016811 cites W2083737302 @default.
- W1974016811 cites W2085741440 @default.
- W1974016811 cites W2087717265 @default.
- W1974016811 cites W2089060791 @default.
- W1974016811 cites W2089844380 @default.
- W1974016811 cites W2091814579 @default.
- W1974016811 cites W2091930319 @default.
- W1974016811 cites W2093427530 @default.
- W1974016811 cites W2093991809 @default.
- W1974016811 cites W2096578491 @default.
- W1974016811 cites W2100585044 @default.
- W1974016811 cites W2102537411 @default.
- W1974016811 cites W2103147774 @default.
- W1974016811 cites W2103553417 @default.
- W1974016811 cites W2111657224 @default.
- W1974016811 cites W2115568450 @default.
- W1974016811 cites W2116249671 @default.
- W1974016811 cites W2117110882 @default.
- W1974016811 cites W2117434378 @default.
- W1974016811 cites W2119773864 @default.
- W1974016811 cites W2120061849 @default.
- W1974016811 cites W2120450091 @default.
- W1974016811 cites W2122105886 @default.
- W1974016811 cites W2125033177 @default.
- W1974016811 cites W2127215601 @default.
- W1974016811 cites W2128103629 @default.
- W1974016811 cites W2128327531 @default.
- W1974016811 cites W2130370518 @default.
- W1974016811 cites W2131818384 @default.
- W1974016811 cites W2133183053 @default.
- W1974016811 cites W2134397849 @default.
- W1974016811 cites W2137749481 @default.
- W1974016811 cites W2137959581 @default.
- W1974016811 cites W2140819820 @default.
- W1974016811 cites W2144921766 @default.
- W1974016811 cites W2145564764 @default.