FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1974022785> ?p ?o ?g. }

• W1974022785 abstract "The present studies determined the role of tumor necrosis factor (TNF)/tumor necrosis factor receptor (TNFR) interactions on cytolytic (CTL) activity of splenic and intrahepatic lymphocytes (IHL) isolated from mice undergoing graft versus host disease, induced by transfer of B6 T cells to major histocompatibility complex (MHC) class I disparate bm1 × B6 F1 mice. Allospecific killing of anti-H-2(bm1) splenic and hepatocyte targets was assessed by 4-h (51)Cr release and 16-h DNA lysis assays, respectively, utilizing spleen cells (SpC) and IHL isolated (1) from sublethally irradiated bm1 × B6 F1 who had received B6 spleen and bone marrow cells, and a control adenovirus (Adv-βgal) or a TNF inhibitor expressing adenovirus (Adv-TNFi), or (2) from bm1 × B6 F1 recipients of B6, B6.129-Tnfrsf1a(tm1Mak)/J (TNFR1(-/-)), B6.129S2-Tnfrsf1b(tm1Mwm)/J (TNFR2(-/-)), or B6.129S-Tnfrsf1a(tm1Imx) Tnfrsf1b(tm1Imx)/J (TNFR(-/-)) SpC and bone marrow cells, or (3) from in vitro-activated SpC. Splenic and IHL from bone marrow transplant recipients who had received Adv-TNFi at the time of transplant displayed lower allospecific CTL activity than controls. Addition of TNFR-Ig or a TNF antibody before the CTL activity assay further reduced allospecific killing against bm1 SpC blast targets. Both TNF/TNFR1 and TNF/TNFR2 interactions were critical for the development of optimal CTL activity against allospecific hepatocyte targets. Further, TNFR1- and TNFR2-deficient SpC from MHC class I disparate mixed lymphocyte cultures displayed lower CTL activity and expression of effector molecules than control B6 SpC. TNF/TNFR interactions were critical for the development of optimal CTL activity of IHL and splenic cytotoxic T cells against MHC class I disparate SpC blast and hepatocyte targets in MHC class I disparate graft versus host disease." @default.
• W1974022785 created "2016-06-24" @default.
• W1974022785 creator A5009288786 @default.
• W1974022785 creator A5010663756 @default.
• W1974022785 creator A5048018872 @default.
• W1974022785 creator A5050927176 @default.
• W1974022785 creator A5071155273 @default.
• W1974022785 date "2011-05-01" @default.
• W1974022785 modified "2023-09-26" @default.
• W1974022785 title "Tumor Necrosis Factor Is Critical for Cytolytic T Cell Activity Against Allospecific Hepatocytes and Splenic Targets in Major Histocompatibility Complex Class I Disparate Graft Versus Host Disease" @default.
• W1974022785 cites W1526571057 @default.
• W1974022785 cites W1536531240 @default.
• W1974022785 cites W1601692989 @default.
• W1974022785 cites W1920417226 @default.
• W1974022785 cites W1964098195 @default.
• W1974022785 cites W1978124798 @default.
• W1974022785 cites W2002451840 @default.
• W1974022785 cites W2003512093 @default.
• W1974022785 cites W2011122387 @default.
• W1974022785 cites W2016948174 @default.
• W1974022785 cites W2026046657 @default.
• W1974022785 cites W2046079641 @default.
• W1974022785 cites W2054763048 @default.
• W1974022785 cites W2059271501 @default.
• W1974022785 cites W2066656786 @default.
• W1974022785 cites W2080094998 @default.
• W1974022785 cites W2090779203 @default.
• W1974022785 cites W2094292853 @default.
• W1974022785 cites W2142911739 @default.
• W1974022785 cites W2151755269 @default.
• W1974022785 cites W2152605128 @default.
• W1974022785 cites W2160950337 @default.
• W1974022785 cites W2169004170 @default.
• W1974022785 cites W2279252100 @default.
• W1974022785 cites W330966458 @default.
• W1974022785 doi "https://doi.org/10.1089/jir.2010.0104" @default.
• W1974022785 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3083722" @default.
• W1974022785 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/21091241" @default.
• W1974022785 hasPublicationYear "2011" @default.
• W1974022785 type Work @default.
• W1974022785 sameAs 1974022785 @default.
• W1974022785 citedByCount "0" @default.
• W1974022785 crossrefType "journal-article" @default.
• W1974022785 hasAuthorship W1974022785A5009288786 @default.
• W1974022785 hasAuthorship W1974022785A5010663756 @default.
• W1974022785 hasAuthorship W1974022785A5048018872 @default.
• W1974022785 hasAuthorship W1974022785A5050927176 @default.
• W1974022785 hasAuthorship W1974022785A5071155273 @default.
• W1974022785 hasBestOaLocation W19740227852 @default.
• W1974022785 hasConcept C109316439 @default.
• W1974022785 hasConcept C142724271 @default.
• W1974022785 hasConcept C147483822 @default.
• W1974022785 hasConcept C159654299 @default.
• W1974022785 hasConcept C170286685 @default.
• W1974022785 hasConcept C17991360 @default.
• W1974022785 hasConcept C188280979 @default.
• W1974022785 hasConcept C202751555 @default.
• W1974022785 hasConcept C202965653 @default.
• W1974022785 hasConcept C203014093 @default.
• W1974022785 hasConcept C207936829 @default.
• W1974022785 hasConcept C2778453870 @default.
• W1974022785 hasConcept C2779134260 @default.
• W1974022785 hasConcept C2779972918 @default.
• W1974022785 hasConcept C28328180 @default.
• W1974022785 hasConcept C3020084786 @default.
• W1974022785 hasConcept C54355233 @default.
• W1974022785 hasConcept C71924100 @default.
• W1974022785 hasConcept C73588182 @default.
• W1974022785 hasConcept C86803240 @default.
• W1974022785 hasConceptScore W1974022785C109316439 @default.
• W1974022785 hasConceptScore W1974022785C142724271 @default.
• W1974022785 hasConceptScore W1974022785C147483822 @default.
• W1974022785 hasConceptScore W1974022785C159654299 @default.
• W1974022785 hasConceptScore W1974022785C170286685 @default.
• W1974022785 hasConceptScore W1974022785C17991360 @default.
• W1974022785 hasConceptScore W1974022785C188280979 @default.
• W1974022785 hasConceptScore W1974022785C202751555 @default.
• W1974022785 hasConceptScore W1974022785C202965653 @default.
• W1974022785 hasConceptScore W1974022785C203014093 @default.
• W1974022785 hasConceptScore W1974022785C207936829 @default.
• W1974022785 hasConceptScore W1974022785C2778453870 @default.
• W1974022785 hasConceptScore W1974022785C2779134260 @default.
• W1974022785 hasConceptScore W1974022785C2779972918 @default.
• W1974022785 hasConceptScore W1974022785C28328180 @default.
• W1974022785 hasConceptScore W1974022785C3020084786 @default.
• W1974022785 hasConceptScore W1974022785C54355233 @default.
• W1974022785 hasConceptScore W1974022785C71924100 @default.
• W1974022785 hasConceptScore W1974022785C73588182 @default.
• W1974022785 hasConceptScore W1974022785C86803240 @default.
• W1974022785 hasLocation W19740227851 @default.
• W1974022785 hasLocation W19740227852 @default.
• W1974022785 hasLocation W19740227853 @default.
• W1974022785 hasLocation W19740227854 @default.
• W1974022785 hasOpenAccess W1974022785 @default.
• W1974022785 hasPrimaryLocation W19740227851 @default.
• W1974022785 hasRelatedWork W1667620412 @default.
• W1974022785 hasRelatedWork W1708153904 @default.
• W1974022785 hasRelatedWork W1966577330 @default.
• W1974022785 hasRelatedWork W1967247828 @default.
• W1974022785 hasRelatedWork W1968856307 @default.

• next