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• W1974022934 abstract "Cloning of cDNAs that code for GABAA receptor subunits has revealed multiple receptor populations constructed from different subunit combinations. On native rat and cloned human GABAA receptors, the anticonvulsant compound loreclezole strongly potentiated GABA-mediated chloride currents. Using different combinations of human GABAA receptor subunits expressed in Xenopus oocytes and transfected 293 cells, loreclezole was highly selective for receptors containing the beta 2 or beta 3 subunit over those containing the beta 1 subunit. Loreclezole was demonstrated to act at a site distinct from the benzodiazepine, barbiturate, and steroid sites with a unique subunit dependence. These results describe a previously unidentified modulatory site on the GABAA receptor beta subunit that allows pharmacological discrimination of different GABAA receptor subpopulations in the brain and provides a new target for putative anticonvulsant/anxiolytic drugs." @default.
• W1974022934 created "2016-06-24" @default.
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• W1974022934 date "1994-04-01" @default.
• W1974022934 modified "2023-10-13" @default.
• W1974022934 title "A novel allosteric modulatory site on the GABAA receptor β subunit" @default.
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• W1974022934 doi "https://doi.org/10.1016/0896-6273(94)90330-1" @default.
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