FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1974025897> ?p ?o ?g. }

• W1974025897 endingPage "3202" @default.
• W1974025897 startingPage "3196" @default.
• W1974025897 abstract "Cushing’s disease refers specifically to an ACTH-producing pituitary adenoma that stimulates excess cortisol production. Trans-sphenoidal surgery is the treatment of choice in children and adolescents, but disparate cure rates have been reported, ranging from 50–98%. The discrepancies in cure rate are due primarily to the technical success of the surgery and the length and method of follow-up. We studied 42 consecutive children and adolescents (age,≤ 18 yr) who underwent transsphenoidal exploration for the primary treatment of Cushing’s disease at University of California-San Francisco from 1974–1993. Only 7 patients had persistent disease, defined as evidence of Cushing’s disease within 6 months of surgery, yielding an initial remission rate of 83%. We comprehensively evaluated 26 of the 35 patients who experienced an initial remission, including testing of the ACTH-adrenocortical axis. The mean duration of follow-up is 7.2 yr (range, 1.5–13.6 yr). Seven experienced a relapse of Cushing’s disease, yielding a net remission rate of 73%. Relapses occurred an average of 4.2 yr postoperatively (range, 0.75–6.2 yr). Five patients experienced relapse within 5 yr of surgery, whereas 2 relapsed more than 5 yr postoperatively. Repeat transsphenoidal surgery was performed in 8 patients with persistent or recurrent disease, and 6 of these remain in remission. Low serum or urinary cortisol measurements within the first post-operative week predicted remission of Cushing’s disease, but were not necessarily predictive of long-term cure. Hypercortisolism had significant effects on bone metabolism, as reflected by both diminished bone density in the majority of patients examined and decreased growth rate. Both parameters improved after surgical care, although they did not fully normalize. We conclude that transsphenoidal surgery is a safe and effective treatment for pediatric Cushing’s disease, but long-term surveillance is necessary to detect possible recurrences." @default.
• W1974025897 created "2016-06-24" @default.
• W1974025897 creator A5011827648 @default.
• W1974025897 creator A5012126365 @default.
• W1974025897 creator A5040216391 @default.
• W1974025897 creator A5064575852 @default.
• W1974025897 creator A5065718203 @default.
• W1974025897 creator A5065964487 @default.
• W1974025897 creator A5074742125 @default.
• W1974025897 creator A5091635904 @default.
• W1974025897 date "1997-10-01" @default.
• W1974025897 modified "2023-10-04" @default.
• W1974025897 title "Long-Term Outcome in Children and Adolescents after Transsphenoidal Surgery for Cushing’s Disease1" @default.
• W1974025897 cites W1608939709 @default.
• W1974025897 cites W1981205460 @default.
• W1974025897 cites W1987610912 @default.
• W1974025897 cites W1992503589 @default.
• W1974025897 cites W1992786401 @default.
• W1974025897 cites W1994699209 @default.
• W1974025897 cites W2000378947 @default.
• W1974025897 cites W2017027985 @default.
• W1974025897 cites W2018299169 @default.
• W1974025897 cites W2019414010 @default.
• W1974025897 cites W2024083192 @default.
• W1974025897 cites W2036633142 @default.
• W1974025897 cites W2037106265 @default.
• W1974025897 cites W2039760382 @default.
• W1974025897 cites W2039911691 @default.
• W1974025897 cites W2056581476 @default.
• W1974025897 cites W2063081075 @default.
• W1974025897 cites W2063236444 @default.
• W1974025897 cites W2068802256 @default.
• W1974025897 cites W2078026864 @default.
• W1974025897 cites W2105089379 @default.
• W1974025897 cites W2128149282 @default.
• W1974025897 cites W2141667316 @default.
• W1974025897 cites W2142292817 @default.
• W1974025897 cites W2157221423 @default.
• W1974025897 cites W2165419265 @default.
• W1974025897 cites W2167290554 @default.
• W1974025897 cites W2332300541 @default.
• W1974025897 cites W2334224196 @default.
• W1974025897 cites W2615509544 @default.
• W1974025897 cites W2999510508 @default.
• W1974025897 cites W2094714409 @default.
• W1974025897 doi "https://doi.org/10.1210/jcem.82.10.4290" @default.
• W1974025897 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/9329338" @default.
• W1974025897 hasPublicationYear "1997" @default.
• W1974025897 type Work @default.
• W1974025897 sameAs 1974025897 @default.
• W1974025897 citedByCount "64" @default.
• W1974025897 countsByYear W19740258972012 @default.
• W1974025897 countsByYear W19740258972013 @default.
• W1974025897 countsByYear W19740258972015 @default.
• W1974025897 countsByYear W19740258972016 @default.
• W1974025897 countsByYear W19740258972017 @default.
• W1974025897 countsByYear W19740258972018 @default.
• W1974025897 countsByYear W19740258972019 @default.
• W1974025897 countsByYear W19740258972020 @default.
• W1974025897 countsByYear W19740258972021 @default.
• W1974025897 countsByYear W19740258972022 @default.
• W1974025897 countsByYear W19740258972023 @default.
• W1974025897 crossrefType "journal-article" @default.
• W1974025897 hasAuthorship W1974025897A5011827648 @default.
• W1974025897 hasAuthorship W1974025897A5012126365 @default.
• W1974025897 hasAuthorship W1974025897A5040216391 @default.
• W1974025897 hasAuthorship W1974025897A5064575852 @default.
• W1974025897 hasAuthorship W1974025897A5065718203 @default.
• W1974025897 hasAuthorship W1974025897A5065964487 @default.
• W1974025897 hasAuthorship W1974025897A5074742125 @default.
• W1974025897 hasAuthorship W1974025897A5091635904 @default.
• W1974025897 hasBestOaLocation W19740258971 @default.
• W1974025897 hasConcept C126322002 @default.
• W1974025897 hasConcept C141071460 @default.
• W1974025897 hasConcept C2776810848 @default.
• W1974025897 hasConcept C2777428134 @default.
• W1974025897 hasConcept C2779134260 @default.
• W1974025897 hasConcept C2779318953 @default.
• W1974025897 hasConcept C2779435821 @default.
• W1974025897 hasConcept C2779653919 @default.
• W1974025897 hasConcept C2910559741 @default.
• W1974025897 hasConcept C71924100 @default.
• W1974025897 hasConceptScore W1974025897C126322002 @default.
• W1974025897 hasConceptScore W1974025897C141071460 @default.
• W1974025897 hasConceptScore W1974025897C2776810848 @default.
• W1974025897 hasConceptScore W1974025897C2777428134 @default.
• W1974025897 hasConceptScore W1974025897C2779134260 @default.
• W1974025897 hasConceptScore W1974025897C2779318953 @default.
• W1974025897 hasConceptScore W1974025897C2779435821 @default.
• W1974025897 hasConceptScore W1974025897C2779653919 @default.
• W1974025897 hasConceptScore W1974025897C2910559741 @default.
• W1974025897 hasConceptScore W1974025897C71924100 @default.
• W1974025897 hasIssue "10" @default.
• W1974025897 hasLocation W19740258971 @default.
• W1974025897 hasLocation W19740258972 @default.
• W1974025897 hasOpenAccess W1974025897 @default.
• W1974025897 hasPrimaryLocation W19740258971 @default.
• W1974025897 hasRelatedWork W1974025897 @default.

• next