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• W1974026272 startingPage "382" @default.
• W1974026272 abstract "Rats received a midthoracic spinal cord “overhemisection” including right hemicord and left dorsal funiculus at birth (neonatal operates, N = 15) or 21 days of age (weanling operates, N = 14). In a second experiment neonatal (N = 6), 6-day (N = 3), and 12-day (N = 7) rats sustained a right sensorimotor cortex (SmI) ablation to destroy the left corticospinal tract (CST) at the same time as the spinal injury (double lesion operates). Later (3–12 months) injections of 3H-proline and autoradiography were used to label the left or right CST. The results of the first experiment showed that most right CST axons failed to grow around the spinal lesion in neonatal operates (N = 9). There was an increase in the density of label, mainly to CST projection areas, in a 1-mm zone rostral to the lesion. However, left CST axons bypassed the lesion by growing through the intact tissue in neonatal operates (N = 6). These displaced axons were consistently located within the dorsal portion of the lateral funiculus (dLF) and remained within that location caudal to the lesion, an area normally containing only a few CST axons. In spite of this abnormal position, these axons terminated bilaterally throughout the remainder of the cord in normal CST sites. In weanling operates, CST axons severed by the lesion did not regenerate around the lesion site. An increased density of label over the few spared axons within the left dLF and in CST projection zones immediately caudal to the lesion site suggested axonal sprouting by these axons. The results of the second experiment showed that the lack of growth of right CST axons around this injury in neonatal operates was, at least partially, due to an interaction with left CST axons. In neonatal double lesion operates, right CST axons grew around the spinal injury for a varying distance within the left dLF and distributed bilaterally to normal CST sites. The number of right CST axons bypassing the lesion was related to the configuration of the lesion site. A smaller number of right CST axons bypassed the lesion in 6-day double lesion operates and most terminated within 2–3 mm of the lesion site. Right CST axons failed to grow around this injury in 12-day double lesion operates. We conclude that the availability of intact spinal cord tissue allows uncut developing left CST axons to grow around a lesion when their primary pathway is destroyed. Differences in growth of left and right CST axons appear to be related to an interaction between left and right CST axons which limits the growth of right CST axons across the midline. The ability for CST axons to grow around this injury decreases at the time these axons are elongating through this region and ceases at the time synapses are being formed by these axons. However, further experiments are necessary to determine if these factors in the maturation of the CST, of if other factor in the maturation of the spinal cord, are critical in limiting CST groth after spinal injuryin the developing CNS." @default.
• W1974026272 created "2016-06-24" @default.
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• W1974026272 date "1983-12-20" @default.
• W1974026272 modified "2023-10-16" @default.
• W1974026272 title "Plasticity of the corticospinal tract following midthoracic spinal injury in the postnatal rat" @default.
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• W1974026272 cites W1978268702 @default.
• W1974026272 cites W1989198443 @default.
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• W1974026272 doi "https://doi.org/10.1002/cne.902210403" @default.
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