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- W1974031930 abstract "The zinc finger transcription factor ZNF24 is a relatively uncharacterized Krüppel-like transcription factor, displaying a suppressive effect on the transcription. ZNF24 is involved in negative regulation of vascular endothelial growth factor (VEGF) and may represent a novel repressor of VEGF transcription. In a previous study, our analysis reveals that ZNF24 is a pleiotropic factor that has a role in hematopoiesis, brain development and cancers. Activation of PDGFR-β is critically involved into various cell functions including recruitment of stromal cells and VEGF induction in tumor and perivascular cells. Here, overexpression of ZNF24 resulted in a significant down-regulation of PDGFR-β, whereas silencing of ZNF24 with small interfering RNA led to increased PDGFR-β expression. Overexpression of ZNF24 resulted in a significant decrease in PDGFR-β promoter activity. These data suggest that ZNF24 is involved in negative regulation of PDGFR-β and may represent a novel repressor of PDGFR-β transcription." @default.
- W1974031930 created "2016-06-24" @default.
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- W1974031930 date "2010-06-01" @default.
- W1974031930 modified "2023-10-14" @default.
- W1974031930 title "The transcriptional repression of platelet-derived growth factor receptor-β by the zinc finger transcription factor ZNF24" @default.
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- W1974031930 doi "https://doi.org/10.1016/j.bbrc.2010.05.110" @default.
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