Matches in SemOpenAlex for { <https://semopenalex.org/work/W1974037019> ?p ?o ?g. }
Showing items 1 to 94 of
94
with 100 items per page.
- W1974037019 endingPage "852" @default.
- W1974037019 startingPage "847" @default.
- W1974037019 abstract "The effects of diethyldithiocarbamate (DDC), a metabolite of disulfiram which is known as Antabuse, on the blood concentrations of alcohol and acetaldehyde were determined simultaneously by head space gas chromatography in rats. After an intravenous injection of alcohol, the blood concentration of acetaldehyde was much lower than that of the alcohol. A pharmacokinetic model featuring the liver compartment for acetaldehyde was used to estimate pharmacokinetic parameters on the assumption that the distribution volumes of the central compartments were same for alcohol and acetaldehyde, and that the elimination rate of acetaldehyde from liver was large enough to isolate the liver compartment from the central compartment. The results showed that the clearance of alcohol was 0.0226 l/min/kg and the elimination rate constant of acetaldehyde from the liver compartment was very large and 35 min-1. The administration of DDC decreased the above significantly to 0.0132 l/min/kg and 20 min-1, respectively. After intravenous infusion of acetaldehyde, the time course of the blood concentration of acetaldehyde was analyzed by the one compartment model. The estimated elimination rate constants from blood and the distribution volume were in good agreement with those calculated from blood and the distribution volume were in good agreement with those calculated from alcohol injection, indicating the appropriateness of the method used in this study. DDC had no effect on the elimination of infused acetaldehyde from blood indicating that the elimination may be due to the loss from lungs into breath, from skin surfaces and/or from the kidney but not by metabolism in the liver." @default.
- W1974037019 created "2016-06-24" @default.
- W1974037019 creator A5009230292 @default.
- W1974037019 creator A5028754419 @default.
- W1974037019 creator A5055461888 @default.
- W1974037019 creator A5068072500 @default.
- W1974037019 creator A5086039808 @default.
- W1974037019 creator A5091113156 @default.
- W1974037019 date "1985-01-01" @default.
- W1974037019 modified "2023-09-24" @default.
- W1974037019 title "Effects of diethyldithiocarbamate, a metabolite of disulfiram, on the pharmacokinetics of alcohol and acetaldehyde in the rat." @default.
- W1974037019 cites W1749095546 @default.
- W1974037019 cites W2014622954 @default.
- W1974037019 cites W2087526401 @default.
- W1974037019 cites W2265601420 @default.
- W1974037019 doi "https://doi.org/10.1248/bpb1978.8.847" @default.
- W1974037019 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/3005541" @default.
- W1974037019 hasPublicationYear "1985" @default.
- W1974037019 type Work @default.
- W1974037019 sameAs 1974037019 @default.
- W1974037019 citedByCount "4" @default.
- W1974037019 crossrefType "journal-article" @default.
- W1974037019 hasAuthorship W1974037019A5009230292 @default.
- W1974037019 hasAuthorship W1974037019A5028754419 @default.
- W1974037019 hasAuthorship W1974037019A5055461888 @default.
- W1974037019 hasAuthorship W1974037019A5068072500 @default.
- W1974037019 hasAuthorship W1974037019A5086039808 @default.
- W1974037019 hasAuthorship W1974037019A5091113156 @default.
- W1974037019 hasConcept C110121322 @default.
- W1974037019 hasConcept C111368507 @default.
- W1974037019 hasConcept C112705442 @default.
- W1974037019 hasConcept C127313418 @default.
- W1974037019 hasConcept C134306372 @default.
- W1974037019 hasConcept C139254425 @default.
- W1974037019 hasConcept C149151106 @default.
- W1974037019 hasConcept C181199279 @default.
- W1974037019 hasConcept C185592680 @default.
- W1974037019 hasConcept C192670549 @default.
- W1974037019 hasConcept C203635412 @default.
- W1974037019 hasConcept C25747580 @default.
- W1974037019 hasConcept C2777477808 @default.
- W1974037019 hasConcept C2777595113 @default.
- W1974037019 hasConcept C2778523461 @default.
- W1974037019 hasConcept C2780161600 @default.
- W1974037019 hasConcept C2781066024 @default.
- W1974037019 hasConcept C33923547 @default.
- W1974037019 hasConcept C43617362 @default.
- W1974037019 hasConcept C55493867 @default.
- W1974037019 hasConcept C71924100 @default.
- W1974037019 hasConcept C98274493 @default.
- W1974037019 hasConceptScore W1974037019C110121322 @default.
- W1974037019 hasConceptScore W1974037019C111368507 @default.
- W1974037019 hasConceptScore W1974037019C112705442 @default.
- W1974037019 hasConceptScore W1974037019C127313418 @default.
- W1974037019 hasConceptScore W1974037019C134306372 @default.
- W1974037019 hasConceptScore W1974037019C139254425 @default.
- W1974037019 hasConceptScore W1974037019C149151106 @default.
- W1974037019 hasConceptScore W1974037019C181199279 @default.
- W1974037019 hasConceptScore W1974037019C185592680 @default.
- W1974037019 hasConceptScore W1974037019C192670549 @default.
- W1974037019 hasConceptScore W1974037019C203635412 @default.
- W1974037019 hasConceptScore W1974037019C25747580 @default.
- W1974037019 hasConceptScore W1974037019C2777477808 @default.
- W1974037019 hasConceptScore W1974037019C2777595113 @default.
- W1974037019 hasConceptScore W1974037019C2778523461 @default.
- W1974037019 hasConceptScore W1974037019C2780161600 @default.
- W1974037019 hasConceptScore W1974037019C2781066024 @default.
- W1974037019 hasConceptScore W1974037019C33923547 @default.
- W1974037019 hasConceptScore W1974037019C43617362 @default.
- W1974037019 hasConceptScore W1974037019C55493867 @default.
- W1974037019 hasConceptScore W1974037019C71924100 @default.
- W1974037019 hasConceptScore W1974037019C98274493 @default.
- W1974037019 hasIssue "10" @default.
- W1974037019 hasLocation W19740370191 @default.
- W1974037019 hasLocation W19740370192 @default.
- W1974037019 hasOpenAccess W1974037019 @default.
- W1974037019 hasPrimaryLocation W19740370191 @default.
- W1974037019 hasRelatedWork W1966782765 @default.
- W1974037019 hasRelatedWork W1974037019 @default.
- W1974037019 hasRelatedWork W1998227260 @default.
- W1974037019 hasRelatedWork W2007950019 @default.
- W1974037019 hasRelatedWork W2012882007 @default.
- W1974037019 hasRelatedWork W2062791413 @default.
- W1974037019 hasRelatedWork W2245895065 @default.
- W1974037019 hasRelatedWork W2422518845 @default.
- W1974037019 hasRelatedWork W3120625362 @default.
- W1974037019 hasRelatedWork W2415759949 @default.
- W1974037019 hasVolume "8" @default.
- W1974037019 isParatext "false" @default.
- W1974037019 isRetracted "false" @default.
- W1974037019 magId "1974037019" @default.
- W1974037019 workType "article" @default.