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- W1974037274 abstract "Abstract. The effects of oestrogens on the release of thyroxine iodide (T 4 I) and non-T 4 I by the thyroid gland of 6 normal subjects and 3 thyrotrophin (TSH)-treated patients with hypopituitarism were assessed before, during and after treatment with 25 mg of Dienoestrol (Glaxo Lab.), orally, daily, during 8 days. Each subject received an iv injection of 150 μCi of 125 I followed 6 days later by an iv injection of 75 μCi of [ 131 I]T 4 . Blood samples and collections of urine were obtained every 12 h. From plasma and urinary (U) radioactivity, the ratio U[ 125 I]/ U[ 131 I], U[ 125 I]/PB[ 125 I] and U[ 131 I]/PB[ 131 I] were obtained and served to calculate thyroidal iodine release and non-T 4 I secretion by the thyroid gland. T 4 I secretion was equivalent to T 4 I disposal rate obtained by the semilogarithmic regression line of PB[ 131 I]. In normal subjects, oestrogens decreased T 4 I secretion from 491 ± 57 ( sd ) nmol/day to 451 ± 60 nmol ( P < 0.025), while in the same subjects serum TSH increased with oestrogens from 3.3 ± 1.1 to 6.6 ± 2.1 mU/l ( P < 0.01). The non-T 4 I secretion had a mean of 585 ± 307 nmol/day during control, 324 ± 199 nmol during oestrogens ( P < 0.01) and 480 ± 286 nmol after oestrogens ( P < 0.05 vs oestrogens). In the TSH-treated patients oestrogens induced non-significant reductions in T 4 I and non-T 4 I secretion, although total iodine secretion decreased significantly ( P < 0.05). The data is consonant with a partial inhibition by oestrogens of thyroid gland release." @default.
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- W1974037274 date "1982-03-01" @default.
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- W1974037274 title "Inhibition of thyroidal iodine release by oestrogens in euthyroid subjects" @default.
- W1974037274 doi "https://doi.org/10.1530/acta.0.0990386" @default.
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