FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1974042040> ?p ?o ?g. }

• W1974042040 endingPage "2383" @default.
• W1974042040 startingPage "2371" @default.
• W1974042040 abstract "The currently available antithrombotic agents target the interaction of platelet integrin αIIbβ3 (GPIIb-IIIa) with fibrinogen during platelet aggregation. Platelets also bind fibrin formed early during thrombus growth. It was proposed that inhibition of platelet-fibrin interactions may be a necessary and important property of αIIbβ3 antagonists; however, the mechanisms by which αIIbβ3 binds fibrin are uncertain. We have previously identified the γ370-381 sequence (P3) in the γC domain of fibrinogen as the fibrin-specific binding site for αIIbβ3 involved in platelet adhesion and platelet-mediated fibrin clot retraction. In the present study, we have demonstrated that P3 can bind to several discontinuous segments within the αIIb β-propeller domain of αIIbβ3 enriched with negatively charged and aromatic residues. By screening peptide libraries spanning the sequence of the αIIb β-propeller, several sequences were identified as candidate contact sites for P3. Synthetic peptides duplicating these segments inhibited platelet adhesion and clot retraction but not platelet aggregation, supporting the role of these regions in fibrin recognition. Mutant αIIbβ3 receptors in which residues identified as critical for P3 binding were substituted for homologous residues in the I-less integrin αMβ2 exhibited reduced cell adhesion and clot retraction. These residues are different from those that are involved in the coordination of the fibrinogen γ404-411 sequence and from auxiliary sites implicated in binding of soluble fibrinogen. These results map the binding of fibrin to multiple sites in the αIIb β-propeller and further indicate that recognition specificity of αIIbβ3 for fibrin differs from that for soluble fibrinogen." @default.
• W1974042040 created "2016-06-24" @default.
• W1974042040 creator A5042525731 @default.
• W1974042040 creator A5055188565 @default.
• W1974042040 creator A5056101043 @default.
• W1974042040 creator A5057640616 @default.
• W1974042040 creator A5080274586 @default.
• W1974042040 creator A5082188638 @default.
• W1974042040 date "2014-01-01" @default.
• W1974042040 modified "2023-10-16" @default.
• W1974042040 title "The Interaction of Integrin αIIbβ3 with Fibrin Occurs through Multiple Binding Sites in the αIIb β-Propeller Domain" @default.
• W1974042040 cites W121411568 @default.
• W1974042040 cites W1234014522 @default.
• W1974042040 cites W1505258801 @default.
• W1974042040 cites W1507013396 @default.
• W1974042040 cites W1516591371 @default.
• W1974042040 cites W1520666812 @default.
• W1974042040 cites W1524999431 @default.
• W1974042040 cites W1575836576 @default.
• W1974042040 cites W1931265512 @default.
• W1974042040 cites W1966166239 @default.
• W1974042040 cites W1967011350 @default.
• W1974042040 cites W1969632860 @default.
• W1974042040 cites W1970314984 @default.
• W1974042040 cites W1972282939 @default.
• W1974042040 cites W1978812749 @default.
• W1974042040 cites W1981528961 @default.
• W1974042040 cites W1984005393 @default.
• W1974042040 cites W1985425331 @default.
• W1974042040 cites W1986586769 @default.
• W1974042040 cites W2002060126 @default.
• W1974042040 cites W2007423256 @default.
• W1974042040 cites W2015332717 @default.
• W1974042040 cites W2016916867 @default.
• W1974042040 cites W2022372977 @default.
• W1974042040 cites W2023122926 @default.
• W1974042040 cites W2029196614 @default.
• W1974042040 cites W2030806904 @default.
• W1974042040 cites W2034215768 @default.
• W1974042040 cites W2044324500 @default.
• W1974042040 cites W2047176113 @default.
• W1974042040 cites W2047838167 @default.
• W1974042040 cites W2054164838 @default.
• W1974042040 cites W2067836657 @default.
• W1974042040 cites W2068180204 @default.
• W1974042040 cites W2068485586 @default.
• W1974042040 cites W2072348189 @default.
• W1974042040 cites W2073150096 @default.
• W1974042040 cites W2075612539 @default.
• W1974042040 cites W2087625365 @default.
• W1974042040 cites W2090501412 @default.
• W1974042040 cites W2109421983 @default.
• W1974042040 cites W2138408888 @default.
• W1974042040 cites W2138991387 @default.
• W1974042040 cites W2150670309 @default.
• W1974042040 cites W2158832664 @default.
• W1974042040 cites W2172028378 @default.
• W1974042040 cites W2291676702 @default.
• W1974042040 cites W2299024552 @default.
• W1974042040 cites W2406745790 @default.
• W1974042040 cites W2415667379 @default.
• W1974042040 cites W2417508769 @default.
• W1974042040 cites W4235269381 @default.
• W1974042040 cites W4239882846 @default.
• W1974042040 cites W49012675 @default.
• W1974042040 cites W954311950 @default.
• W1974042040 doi "https://doi.org/10.1074/jbc.m113.518126" @default.
• W1974042040 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3900980" @default.
• W1974042040 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/24338009" @default.
• W1974042040 hasPublicationYear "2014" @default.
• W1974042040 type Work @default.
• W1974042040 sameAs 1974042040 @default.
• W1974042040 citedByCount "46" @default.
• W1974042040 countsByYear W19740420402015 @default.
• W1974042040 countsByYear W19740420402016 @default.
• W1974042040 countsByYear W19740420402017 @default.
• W1974042040 countsByYear W19740420402018 @default.
• W1974042040 countsByYear W19740420402019 @default.
• W1974042040 countsByYear W19740420402020 @default.
• W1974042040 countsByYear W19740420402021 @default.
• W1974042040 countsByYear W19740420402022 @default.
• W1974042040 countsByYear W19740420402023 @default.
• W1974042040 crossrefType "journal-article" @default.
• W1974042040 hasAuthorship W1974042040A5042525731 @default.
• W1974042040 hasAuthorship W1974042040A5055188565 @default.
• W1974042040 hasAuthorship W1974042040A5056101043 @default.
• W1974042040 hasAuthorship W1974042040A5057640616 @default.
• W1974042040 hasAuthorship W1974042040A5080274586 @default.
• W1974042040 hasAuthorship W1974042040A5082188638 @default.
• W1974042040 hasBestOaLocation W19740420401 @default.
• W1974042040 hasConcept C107824862 @default.
• W1974042040 hasConcept C12554922 @default.
• W1974042040 hasConcept C170493617 @default.
• W1974042040 hasConcept C185592680 @default.
• W1974042040 hasConcept C195687474 @default.
• W1974042040 hasConcept C203014093 @default.
• W1974042040 hasConcept C2777292125 @default.
• W1974042040 hasConcept C2778863912 @default.

• next