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• W1974043829 startingPage "31458" @default.
• W1974043829 abstract "We have found that the integrin β3 chain can be phosphorylated on tyrosine residues in K562 cells transfected with αvβ3. Tyrosine phosphorylation of the β3 cytoplasmic tail is induced by adhesion to αvβ3-specific ligand or antibody or by incubation in manganese-containing buffer. Under the same conditions, β5 does not become tyrosine-phosphorylated in K562 transfected with αvβ5. Phosphorylation of the β3 subunit requires the simultaneous presence of the αv subunit cytoplasmic tail, because neither the αIIb subunit nor a truncated αv subunit is sufficient to permit phosphorylation of β3 when coexpressed as a heterodimer with β3. Finally, tyrosine phosphorylation of the β3 cytoplasmic tail occurs on both human and murine β3 and is inducible in the ovarian carcinoma OV10 as well, independent of expression of integrin-associated protein (CD47). Tyrosine phosphorylation of the β3 integrin subunit facilitates association of Grb-2, an adaptor protein leading to activation of the Ras signaling pathway, and may contribute to the unique functional and signaling capabilities of αvβ3. We have found that the integrin β3 chain can be phosphorylated on tyrosine residues in K562 cells transfected with αvβ3. Tyrosine phosphorylation of the β3 cytoplasmic tail is induced by adhesion to αvβ3-specific ligand or antibody or by incubation in manganese-containing buffer. Under the same conditions, β5 does not become tyrosine-phosphorylated in K562 transfected with αvβ5. Phosphorylation of the β3 subunit requires the simultaneous presence of the αv subunit cytoplasmic tail, because neither the αIIb subunit nor a truncated αv subunit is sufficient to permit phosphorylation of β3 when coexpressed as a heterodimer with β3. Finally, tyrosine phosphorylation of the β3 cytoplasmic tail occurs on both human and murine β3 and is inducible in the ovarian carcinoma OV10 as well, independent of expression of integrin-associated protein (CD47). Tyrosine phosphorylation of the β3 integrin subunit facilitates association of Grb-2, an adaptor protein leading to activation of the Ras signaling pathway, and may contribute to the unique functional and signaling capabilities of αvβ3." @default.
• W1974043829 created "2016-06-24" @default.
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• W1974043829 date "1996-12-01" @default.
• W1974043829 modified "2023-10-09" @default.
• W1974043829 title "Inducible Tyrosine Phosphorylation of the β3 Integrin Requires the αv Integrin Cytoplasmic Tail" @default.
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• W1974043829 doi "https://doi.org/10.1074/jbc.271.49.31458" @default.
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