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- W1974044629 abstract "Amineptine differs from classic Tricyclic Anti-Depressants (TAD) because of the insertion of an amino-acidic chain of seven carbon atoms linked to the central nucleus. This gives the molecule a selectively dopaminergic action (Duizabo 1980; Borsini et al 1981) as it increases the release and reduces the reuptake of dopamine (Samanin et al 1977; Offermeier et al 1977). It is virtually devoid of anticholinergic, serotoninergic, and noradrenergic effects at therapeutic posology (Both'in et al 1982), but effect on serotonin can be observed at high doses. From a clinical viewpoint we know that the drug has a reversible toxicity on the liver (Bel and Girard 1981); furthermore it is reported to have a rapid effect (Van Amerongen 1979, Deniker et al 1982; Rosier 1979), without the TAD's characteristic time-lag (Rosier 1979; Bomstein 1979), but this could lead certain patients to abuse it. Five cases of amineptine addiction have been documented (Tremine et al 1983; Ginestet et al 1984; Abati and Giovacchini 1986; Stella et ai 1986), and in 1 case, a possible amphetamine-like psychosis has been reported (Trerrtine et al 1983) since this drag was introduced on the market (1978 in France and 1983 in Italy, where, according to marketing data, it represents 6.4% of all antidepressants, with 928,300 prescriptions in 1989). In the last few months, 2 cases of amineptine abuse have been brought to our attention alraost contemporaneously; both were admitted to the Toxicology Ward at the Florence University School of Medicine." @default.
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- W1974044629 date "1990-12-01" @default.
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- W1974044629 title "Chronic amineptine abuse" @default.
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- W1974044629 doi "https://doi.org/10.1016/0006-3223(90)90066-b" @default.
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