FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1974050323> ?p ?o ?g. }

• W1974050323 endingPage "4858" @default.
• W1974050323 startingPage "4849" @default.
• W1974050323 abstract "Group B streptococcus (GBS) is a major cause of neonatal sepsis and meningitis. Despite aggressive campaigns using antenatal prophylactic antibiotic therapy, infections continue. Developing an effective maternal vaccine is a public health priority. Antibody (Ab) to the capsular polysaccharide (CPS) is considered the dominant “protective” immune mediator. Here we study the fine specificity and potential host reactivity of a panel of well-characterized murine monoclonal Abs against the type III CPS by examining the binding of the Abs to intact and neuraminidase-digested GBS, purified CPS, synthetic carbohydrate structures, and cells. The results showed marked differences in the fine specificity among these mAbs to a single carbohydrate structure. Cross-reactions with synthetic GD3 and GT3 carbohydrates, representing structures found on surfaces of neural and developing cells, were demonstrated using carbohydrate array technology. The anti-CPSIII mAbs did not react with cells expressing GD3 and GT3, nor did mAbs specific for the host carbohydrates cross-react with GBS, raising questions about the physiological relevance of this cross-reaction. But in the process of these investigations, we serendipitously demonstrated cross-reactions of some anti-CPSIII mAbs with antigens, likely carbohydrates, found on human leukocytes. These studies suggest caution in the development of a maternal vaccine to prevent infection by this important human pathogen." @default.
• W1974050323 created "2016-06-24" @default.
• W1974050323 creator A5031462808 @default.
• W1974050323 creator A5031908143 @default.
• W1974050323 creator A5045613701 @default.
• W1974050323 creator A5048417222 @default.
• W1974050323 creator A5049360221 @default.
• W1974050323 creator A5049938979 @default.
• W1974050323 creator A5051235093 @default.
• W1974050323 date "2012-07-01" @default.
• W1974050323 modified "2023-10-16" @default.
• W1974050323 title "Fine specificity and cross-reactions of monoclonal antibodies to group B streptococcal capsular polysaccharide type III" @default.
• W1974050323 cites W1514938122 @default.
• W1974050323 cites W1522361063 @default.
• W1974050323 cites W1543731498 @default.
• W1974050323 cites W1604526276 @default.
• W1974050323 cites W1830300067 @default.
• W1974050323 cites W1895018631 @default.
• W1974050323 cites W1910048176 @default.
• W1974050323 cites W1915391240 @default.
• W1974050323 cites W1926094917 @default.
• W1974050323 cites W1930023791 @default.
• W1974050323 cites W1946657055 @default.
• W1974050323 cites W1972420743 @default.
• W1974050323 cites W1975149550 @default.
• W1974050323 cites W1975910983 @default.
• W1974050323 cites W1978287409 @default.
• W1974050323 cites W1990874998 @default.
• W1974050323 cites W1992578082 @default.
• W1974050323 cites W1998162049 @default.
• W1974050323 cites W1998436251 @default.
• W1974050323 cites W2000466408 @default.
• W1974050323 cites W2003318904 @default.
• W1974050323 cites W2024070740 @default.
• W1974050323 cites W2026842644 @default.
• W1974050323 cites W2049114658 @default.
• W1974050323 cites W2058659535 @default.
• W1974050323 cites W2076975212 @default.
• W1974050323 cites W2081466013 @default.
• W1974050323 cites W2084807013 @default.
• W1974050323 cites W2090066588 @default.
• W1974050323 cites W2095978295 @default.
• W1974050323 cites W2097150953 @default.
• W1974050323 cites W2097643107 @default.
• W1974050323 cites W2097643820 @default.
• W1974050323 cites W2112556005 @default.
• W1974050323 cites W2112972281 @default.
• W1974050323 cites W2116850184 @default.
• W1974050323 cites W2119399069 @default.
• W1974050323 cites W2127077913 @default.
• W1974050323 cites W2128697027 @default.
• W1974050323 cites W2131492616 @default.
• W1974050323 cites W2136970311 @default.
• W1974050323 cites W2147673959 @default.
• W1974050323 cites W2159875118 @default.
• W1974050323 cites W2168418588 @default.
• W1974050323 cites W2250068495 @default.
• W1974050323 cites W2295798107 @default.
• W1974050323 cites W2336451674 @default.
• W1974050323 cites W2401999330 @default.
• W1974050323 doi "https://doi.org/10.1016/j.vaccine.2012.05.006" @default.
• W1974050323 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3382002" @default.
• W1974050323 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/22634296" @default.
• W1974050323 hasPublicationYear "2012" @default.
• W1974050323 type Work @default.
• W1974050323 sameAs 1974050323 @default.
• W1974050323 citedByCount "8" @default.
• W1974050323 countsByYear W19740503232013 @default.
• W1974050323 countsByYear W19740503232014 @default.
• W1974050323 countsByYear W19740503232015 @default.
• W1974050323 countsByYear W19740503232016 @default.
• W1974050323 countsByYear W19740503232019 @default.
• W1974050323 crossrefType "journal-article" @default.
• W1974050323 hasAuthorship W1974050323A5031462808 @default.
• W1974050323 hasAuthorship W1974050323A5031908143 @default.
• W1974050323 hasAuthorship W1974050323A5045613701 @default.
• W1974050323 hasAuthorship W1974050323A5048417222 @default.
• W1974050323 hasAuthorship W1974050323A5049360221 @default.
• W1974050323 hasAuthorship W1974050323A5049938979 @default.
• W1974050323 hasAuthorship W1974050323A5051235093 @default.
• W1974050323 hasBestOaLocation W19740503232 @default.
• W1974050323 hasConcept C10389963 @default.
• W1974050323 hasConcept C104317684 @default.
• W1974050323 hasConcept C126322002 @default.
• W1974050323 hasConcept C134164806 @default.
• W1974050323 hasConcept C147483822 @default.
• W1974050323 hasConcept C155292618 @default.
• W1974050323 hasConcept C159047783 @default.
• W1974050323 hasConcept C159654299 @default.
• W1974050323 hasConcept C203014093 @default.
• W1974050323 hasConcept C2522874641 @default.
• W1974050323 hasConcept C2775953899 @default.
• W1974050323 hasConcept C2776460866 @default.
• W1974050323 hasConcept C2777860557 @default.
• W1974050323 hasConcept C2778276568 @default.
• W1974050323 hasConcept C2778384902 @default.
• W1974050323 hasConcept C2780678043 @default.
• W1974050323 hasConcept C523546767 @default.

• next