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• W1974054467 abstract "The availability of an antiserum specific for the 11S factor (C′1q), one of the three parts of the first component of complement (C′), permitted estimation of 11S by a simple immunodiffusion method. The 11S concentration of normal human serum was in the range of 18 to 28 γ of 11S nitrogen per cc. Since this component is fixed and removed during complement fixation, 11S levels were compared with total hemolytic complement activity in systemic lupus erythematosus, glomerulonephritis and other conditions possibly involving immune mechanisms. In most patients with active systemic lupus erythematosus, both 11S and C′ levels were low. In subjects with systemic lupus erythematosus in remission, both 11S and C′ tended to be near normal, but slightly lowered C′ levels were not always reflected by 11S measurements. (The 11S concentration, like total C′, is an acute phase reactant, increased in inflammatory states.) In other illnesses, correlation was poor although C′ activity was always diminished when 11S was low. Possible reasons for these discrepancies are discussed and current thoughts on the role of C′ in the pathogenesis of these conditions are reviewed." @default.
• W1974054467 created "2016-06-24" @default.
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• W1974054467 date "1967-06-01" @default.
• W1974054467 modified "2023-09-24" @default.
• W1974054467 title "Clinical studies of hemolytic complement and the 11S component" @default.
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• W1974054467 doi "https://doi.org/10.1016/0002-9343(67)90069-1" @default.
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