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- W1974064446 abstract "Abstract: In recent years it has become apparent that peroxynitrite. which is one of the toxic metabolites originating from the reaction of nitric oxide and superoxide presents a number of pathologic states in which free radicals are thought to be involved. Peroxynitrite is capable of oxidizing a wide variety of biomolecules including plasma, proteins, lipids, carbohydrates and nucleic acids. Peroxynitrite is involved in the hydroxylation of aromatic compounds and acts as a nitrating agent. It modifies free or protein-associated tyrosine residues to give nitrotyrosines, leaving a marker detectable in vivo. Peroxynitrite has been implicated in the pathophysiology of a variety of diseases including inflammation, atherosclerosis, arthritis, endotoxemia, ischaemia-reperfusion injury, or acute respiratory distress syndrome. Development of specific peroxynitrite scavengers may provide new approaches for the effective treatment of these disease states." @default.
- W1974064446 created "2016-06-24" @default.
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- W1974064446 date "1998-03-01" @default.
- W1974064446 modified "2023-10-18" @default.
- W1974064446 title "Peroxynitrite: A Putative Cytotoxin" @default.
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- W1974064446 doi "https://doi.org/10.1111/j.1600-0773.1998.tb01408.x" @default.
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