Matches in SemOpenAlex for { <https://semopenalex.org/work/W1974065293> ?p ?o ?g. }
- W1974065293 endingPage "166" @default.
- W1974065293 startingPage "157" @default.
- W1974065293 abstract "The acute effects of captopril and dobutamine, alone and in combination, on left ventricular contractility were assessed from left ventricular end-systolic pressure-volume and pressure-shortening relations in 6 patients with severe end-stage cardiac failure. Dobutamine was given by constant intravenous infusion on two occasions 48 hours apart, on one of these occasions the patient also received oral captopril in a dose of 37 +/- 12 mg 6-hourly. Pressures and cardiac index were measured, and left ventricular volumes and ejection fraction computed from simultaneously recorded radionuclide ventriculography. Dobutamine alone did not cause a statistically significant increase in stroke index, stroke work index, cardiac index and ejection fraction, although pulmonary capillary wedge pressure and right atrial pressure fell (P less than 0.05). There was no change in systemic or pulmonary vascular resistance nor in arterial blood pressure. Following administration of captopril, diastolic arterial pressure decreased (P less than 0.05), and the dobutamine challenge produced a greater and significant rise in stroke and stroke work index (P less than 0.05) and cardiac index (P less than 0.01). The left ventricular contractile state was unaltered by captopril but appeared to increase with dobutamine and more so during combined therapy with captopril and dobutamine, indicating a synergistic effect of the two drugs when given in combination." @default.
- W1974065293 created "2016-06-24" @default.
- W1974065293 creator A5002556684 @default.
- W1974065293 creator A5019968582 @default.
- W1974065293 creator A5042783511 @default.
- W1974065293 creator A5045642535 @default.
- W1974065293 creator A5046657891 @default.
- W1974065293 creator A5058171167 @default.
- W1974065293 date "1988-11-01" @default.
- W1974065293 modified "2023-09-26" @default.
- W1974065293 title "Synergistic effect of captopril and dobutamine on left ventricular pressure—volume and pressure—shortening relations in severe cardiac failure" @default.
- W1974065293 cites W159187534 @default.
- W1974065293 cites W159394109 @default.
- W1974065293 cites W1973410266 @default.
- W1974065293 cites W1974446027 @default.
- W1974065293 cites W1974884659 @default.
- W1974065293 cites W1988840374 @default.
- W1974065293 cites W1992724992 @default.
- W1974065293 cites W1998245427 @default.
- W1974065293 cites W2009614210 @default.
- W1974065293 cites W2011712672 @default.
- W1974065293 cites W2015700503 @default.
- W1974065293 cites W2022959574 @default.
- W1974065293 cites W2025570286 @default.
- W1974065293 cites W2027938050 @default.
- W1974065293 cites W2028137315 @default.
- W1974065293 cites W2028505223 @default.
- W1974065293 cites W2029055232 @default.
- W1974065293 cites W2033296625 @default.
- W1974065293 cites W2037099369 @default.
- W1974065293 cites W2043057893 @default.
- W1974065293 cites W2048986057 @default.
- W1974065293 cites W2054298503 @default.
- W1974065293 cites W2056828409 @default.
- W1974065293 cites W2061285439 @default.
- W1974065293 cites W2063484017 @default.
- W1974065293 cites W2072353372 @default.
- W1974065293 cites W2072537545 @default.
- W1974065293 cites W2074588774 @default.
- W1974065293 cites W2076486635 @default.
- W1974065293 cites W2081590661 @default.
- W1974065293 cites W2090121413 @default.
- W1974065293 cites W2100483760 @default.
- W1974065293 cites W2119229486 @default.
- W1974065293 cites W2120525089 @default.
- W1974065293 cites W2135761450 @default.
- W1974065293 cites W2143485821 @default.
- W1974065293 cites W2157973908 @default.
- W1974065293 cites W2312437912 @default.
- W1974065293 cites W2325797916 @default.
- W1974065293 cites W2338276426 @default.
- W1974065293 cites W2399852791 @default.
- W1974065293 cites W2400479137 @default.
- W1974065293 cites W2417281657 @default.
- W1974065293 cites W2431814229 @default.
- W1974065293 cites W2594447166 @default.
- W1974065293 doi "https://doi.org/10.1016/0167-5273(88)90218-5" @default.
- W1974065293 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/3066763" @default.
- W1974065293 hasPublicationYear "1988" @default.
- W1974065293 type Work @default.
- W1974065293 sameAs 1974065293 @default.
- W1974065293 citedByCount "0" @default.
- W1974065293 crossrefType "journal-article" @default.
- W1974065293 hasAuthorship W1974065293A5002556684 @default.
- W1974065293 hasAuthorship W1974065293A5019968582 @default.
- W1974065293 hasAuthorship W1974065293A5042783511 @default.
- W1974065293 hasAuthorship W1974065293A5045642535 @default.
- W1974065293 hasAuthorship W1974065293A5046657891 @default.
- W1974065293 hasAuthorship W1974065293A5058171167 @default.
- W1974065293 hasConcept C126322002 @default.
- W1974065293 hasConcept C139940330 @default.
- W1974065293 hasConcept C146556889 @default.
- W1974065293 hasConcept C164705383 @default.
- W1974065293 hasConcept C178853913 @default.
- W1974065293 hasConcept C2778198053 @default.
- W1974065293 hasConcept C2778535784 @default.
- W1974065293 hasConcept C2779479957 @default.
- W1974065293 hasConcept C2781185063 @default.
- W1974065293 hasConcept C31861589 @default.
- W1974065293 hasConcept C42219234 @default.
- W1974065293 hasConcept C58245268 @default.
- W1974065293 hasConcept C71924100 @default.
- W1974065293 hasConcept C78085059 @default.
- W1974065293 hasConcept C80461066 @default.
- W1974065293 hasConcept C84393581 @default.
- W1974065293 hasConceptScore W1974065293C126322002 @default.
- W1974065293 hasConceptScore W1974065293C139940330 @default.
- W1974065293 hasConceptScore W1974065293C146556889 @default.
- W1974065293 hasConceptScore W1974065293C164705383 @default.
- W1974065293 hasConceptScore W1974065293C178853913 @default.
- W1974065293 hasConceptScore W1974065293C2778198053 @default.
- W1974065293 hasConceptScore W1974065293C2778535784 @default.
- W1974065293 hasConceptScore W1974065293C2779479957 @default.
- W1974065293 hasConceptScore W1974065293C2781185063 @default.
- W1974065293 hasConceptScore W1974065293C31861589 @default.
- W1974065293 hasConceptScore W1974065293C42219234 @default.
- W1974065293 hasConceptScore W1974065293C58245268 @default.
- W1974065293 hasConceptScore W1974065293C71924100 @default.