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- W1974065510 abstract "Since paternal age at reproduction is considered to be the main factor determining human spontaneous mutation rate (Crow, J. (1993) Environ. Mol. Mutagenesis, 21, 122-129), the effect of paternal age on human longevity was studied on 8,518 adult persons (at age 30 and above) from European aristocratic families with well-known genealogy. The daughters born to old fathers (50-59 years) lose about 4.4 years of their life compared to daughters of young fathers (20-29 years) and these losses are highly statistically significant, while sons are not significantly affected. Since only daughters inherit the paternal X chromosome, this sex-specific decrease in daughters' longevity might indicate that human longevity genes (crucial, house-keeping genes) sensitive to mutational load might be located in this chromosome." @default.
- W1974065510 created "2016-06-24" @default.
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- W1974065510 date "1997-06-09" @default.
- W1974065510 modified "2023-09-28" @default.
- W1974065510 title "Mutation load and human longevity" @default.
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- W1974065510 doi "https://doi.org/10.1016/s0027-5107(97)00058-4" @default.
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