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• W1974071094 abstract "We have constructed and tested in vitro a potentially implantable, needle-type amperometric enzyme electrode which is suitable for continuous monitoring of glucose concentrations in diabetic patients. The major requirements of stability during operation and ease of manufacture have been met with a sensor design which involves a simple dip-coating procedure for applying to a platinum base electrode an inner membrane of glucose oxidase immobilised in polyhydroxyethyl methacrylate (pHEMA), and an outer membrane composed of a pHEMA/polyurethane mixture. Sensors were operated at 700 mV for detection of hydrogen peroxide. Calibration curves for the sensor were linear to at least 20 mm glucose and were unaffected by a reduction in PO2 from 20 to 5 kPa. During continuous operation in 5 mm buffered glucose solutions in vitro, sensors suffered no significant loss of response over periods of up to 60 h. Such electrodes are, therefore, useful for development as in vivo glucose sensors." @default.
• W1974071094 created "2016-06-24" @default.
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• W1974071094 date "1991-01-01" @default.
• W1974071094 modified "2023-10-01" @default.
• W1974071094 title "In vitro testing of a simply constructed, highly stable glucose sensor suitable for implantation in diabetic patients" @default.
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• W1974071094 doi "https://doi.org/10.1016/0956-5663(91)87004-u" @default.
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