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- W1974072171 abstract "Correct positioning of the centrosome is critical for the survival of the cell. For small and medium-sized cells, the force required to move the centrosome can arise from either microtubule pushing on the cortex, or cortically attached dynein pulling on microtubules. However, in large cells, such as the fertilized Xenopus laevis embryo, where microtubules are too long or they do not reach all boundaries before centrosome centering begins, a different force-generating mechanism must exist. Here, we present a centrosome positioning model in which the cytosolic drag experienced by cargos hauled by cytoplasmic dynein on the sperm aster microtubules can move the centrosome towards the cell's center. As opposed to previously published studies, that conclude that large, slow or stationary, cargoes are required to move the centrosome, we find that small, fast moving cargos (diameter 100nm, cargo velocity 2μm/s) are sufficient to move the centrosome in Xenopus laevis within the experimentally observed length and time scales." @default.
- W1974072171 created "2016-06-24" @default.
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- W1974072171 date "2013-01-01" @default.
- W1974072171 modified "2023-09-28" @default.
- W1974072171 title "Centrosome Positioning in Large Cells via Dynein-Powered Intracellular Cargo Transport" @default.
- W1974072171 doi "https://doi.org/10.1016/j.bpj.2012.11.3592" @default.
- W1974072171 hasPublicationYear "2013" @default.
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