FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1974075705> ?p ?o ?g. }

• W1974075705 endingPage "1773" @default.
• W1974075705 startingPage "1767" @default.
• W1974075705 abstract "Epithelial-mesenchymal transition (EMT) is a process by which cancer cells acquire mesenchymal properties, such as induction of vimentin, while epithelial-associated genes like E-cadherin are lost. This enables cells to be more metastatic. Factors that are able to induce EMT include growth factors such as transforming growth factor-β (TGF-β) and epidermal growth factor, and transcription factors such as Snail. Snail-induced EMT promotes migration and invasion and we hypothesized that this may be mediated by the activity of urokinase-type plasminogen activator (uPA) and its receptor (uPAR). LNCaP, 22Rv1 and ARCaP human prostate cancer (CaP) cells stably transfected with empty vector control (Neo) or constitutively active Snail exhibited increased cell invasion. Superarray analysis revealed an upregulation in uPA and uPAR RNA expression in Snail-transfected ARCaP cells compared with that of a Neo control. In addition, the protein expression levels of Snail, uPA and uPAR were measured by western blot analysis which showed that overexpression of Snail increased uPA and uPAR protein levels. The activity of uPA in conditioned media was measured using an ELISA which revealed that uPA activity was elevated in LNCaP, 22Rv1 and ARCaP cells overexpressing Snail. Additionally, transient silencing of uPAR in ARCaP cells overexpressing Snail using short interfering RNA resulted in abrogation of Snail-mediated invasion. Snail overexpression was associated with increased extracellular-signal-regulated kinase activity, and antagonism of this activity with mitogen-activated protein (MAPK) inhibitor, UO126, inhibited cell invasion and decreased uPA activity. Therefore, Snail-mediated cell invasion in human CaP cells may occur via the regulation of uPA/uPAR and the MAPK signaling pathway." @default.
• W1974075705 created "2016-06-24" @default.
• W1974075705 creator A5006525253 @default.
• W1974075705 creator A5020127181 @default.
• W1974075705 creator A5038943566 @default.
• W1974075705 creator A5088194747 @default.
• W1974075705 date "2013-10-18" @default.
• W1974075705 modified "2023-09-27" @default.
• W1974075705 title "Snail mediates invasion through uPA/uPAR and the MAPK signaling pathway in prostate cancer cells" @default.
• W1974075705 cites W1598733586 @default.
• W1974075705 cites W1760215417 @default.
• W1974075705 cites W1953156003 @default.
• W1974075705 cites W1963502802 @default.
• W1974075705 cites W1969597507 @default.
• W1974075705 cites W1973890143 @default.
• W1974075705 cites W1979002007 @default.
• W1974075705 cites W2004657520 @default.
• W1974075705 cites W2010813562 @default.
• W1974075705 cites W2012080977 @default.
• W1974075705 cites W2019171596 @default.
• W1974075705 cites W2028948507 @default.
• W1974075705 cites W2046042150 @default.
• W1974075705 cites W2048326719 @default.
• W1974075705 cites W2049594731 @default.
• W1974075705 cites W2059128799 @default.
• W1974075705 cites W2059372860 @default.
• W1974075705 cites W2070577749 @default.
• W1974075705 cites W2085351616 @default.
• W1974075705 cites W2086101282 @default.
• W1974075705 cites W2092655018 @default.
• W1974075705 cites W2096065464 @default.
• W1974075705 cites W2096539796 @default.
• W1974075705 cites W2096909126 @default.
• W1974075705 cites W2107630967 @default.
• W1974075705 cites W2109615647 @default.
• W1974075705 cites W2109850844 @default.
• W1974075705 cites W2113616859 @default.
• W1974075705 cites W2119675067 @default.
• W1974075705 cites W2126693477 @default.
• W1974075705 cites W2134203671 @default.
• W1974075705 cites W2146445411 @default.
• W1974075705 cites W2147230623 @default.
• W1974075705 cites W2149271063 @default.
• W1974075705 cites W2150416393 @default.
• W1974075705 cites W2156273277 @default.
• W1974075705 cites W2165901622 @default.
• W1974075705 cites W2165948908 @default.
• W1974075705 cites W2169782238 @default.
• W1974075705 cites W2402194021 @default.
• W1974075705 doi "https://doi.org/10.3892/ol.2013.1635" @default.
• W1974075705 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4738196" @default.
• W1974075705 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/26889270" @default.
• W1974075705 hasPublicationYear "2013" @default.
• W1974075705 type Work @default.
• W1974075705 sameAs 1974075705 @default.
• W1974075705 citedByCount "15" @default.
• W1974075705 countsByYear W19740757052017 @default.
• W1974075705 countsByYear W19740757052018 @default.
• W1974075705 countsByYear W19740757052019 @default.
• W1974075705 countsByYear W19740757052020 @default.
• W1974075705 countsByYear W19740757052021 @default.
• W1974075705 countsByYear W19740757052022 @default.
• W1974075705 crossrefType "journal-article" @default.
• W1974075705 hasAuthorship W1974075705A5006525253 @default.
• W1974075705 hasAuthorship W1974075705A5020127181 @default.
• W1974075705 hasAuthorship W1974075705A5038943566 @default.
• W1974075705 hasAuthorship W1974075705A5088194747 @default.
• W1974075705 hasBestOaLocation W19740757051 @default.
• W1974075705 hasConcept C104317684 @default.
• W1974075705 hasConcept C119056186 @default.
• W1974075705 hasConcept C121608353 @default.
• W1974075705 hasConcept C134018914 @default.
• W1974075705 hasConcept C18903297 @default.
• W1974075705 hasConcept C22615655 @default.
• W1974075705 hasConcept C2779013556 @default.
• W1974075705 hasConcept C2779679481 @default.
• W1974075705 hasConcept C2779723316 @default.
• W1974075705 hasConcept C2779965526 @default.
• W1974075705 hasConcept C502942594 @default.
• W1974075705 hasConcept C54009773 @default.
• W1974075705 hasConcept C54355233 @default.
• W1974075705 hasConcept C55493867 @default.
• W1974075705 hasConcept C56219504 @default.
• W1974075705 hasConcept C57074206 @default.
• W1974075705 hasConcept C62478195 @default.
• W1974075705 hasConcept C76419328 @default.
• W1974075705 hasConcept C81885089 @default.
• W1974075705 hasConcept C86803240 @default.
• W1974075705 hasConcept C95444343 @default.
• W1974075705 hasConcept C96232424 @default.
• W1974075705 hasConceptScore W1974075705C104317684 @default.
• W1974075705 hasConceptScore W1974075705C119056186 @default.
• W1974075705 hasConceptScore W1974075705C121608353 @default.
• W1974075705 hasConceptScore W1974075705C134018914 @default.
• W1974075705 hasConceptScore W1974075705C18903297 @default.
• W1974075705 hasConceptScore W1974075705C22615655 @default.
• W1974075705 hasConceptScore W1974075705C2779013556 @default.
• W1974075705 hasConceptScore W1974075705C2779679481 @default.

• next