FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1974089713> ?p ?o ?g. }

• W1974089713 endingPage "e92198" @default.
• W1974089713 startingPage "e92198" @default.
• W1974089713 abstract "Plasma, the fourth state of matter, is defined as a partially or completely ionized gas that includes a mixture of electrons and ions. Advances in plasma physics have made it possible to use non-thermal atmospheric pressure plasma (NTP) in cancer research. However, previous studies have focused mainly on apoptotic cancer cell death mediated by NTP as a potential cancer therapy. In this study, we investigated the effect of NTP on invasion or metastasis, as well as the mechanism by which plasma induces anti-migration and anti-invasion properties in human thyroid papillary cancer cell lines (BHP10-3 and TPC1). Wound healing, pull-down, and Transwell assays demonstrated that NTP reduced cell migration and invasion. In addition, NTP induced morphological changes and cytoskeletal rearrangements, as detected by scanning electron microscopy and immunocytochemistry. We also examined matrix metalloproteinase (MMP)-2/-9 and urokinase-type plasminogen activator (uPA) activity using gelatin zymography, uPA assays and RT-PCR. FAK, Src, and paxillin expression was detected using Western blot analyses and immunocytochemistry. NTP decreased FAK, Src, and paxillin expression as well as MMP/uPA activity. In conclusion, NTP inhibited the invasion and metastasis of BHP10-3 and TPC1 cells by decreasing MMP-2/-9 and uPA activities and rearranging the cytoskeleton, which is regulated by the FAK/Src complex. These findings suggest novel actions for NTP and may aid in the development of new therapeutic strategies for locally invasive and metastatic cancers." @default.
• W1974089713 created "2016-06-24" @default.
• W1974089713 creator A5004170846 @default.
• W1974089713 creator A5024610841 @default.
• W1974089713 creator A5025705059 @default.
• W1974089713 creator A5037196214 @default.
• W1974089713 creator A5038172025 @default.
• W1974089713 creator A5063870533 @default.
• W1974089713 creator A5077609217 @default.
• W1974089713 creator A5081449876 @default.
• W1974089713 creator A5083028758 @default.
• W1974089713 creator A5066098737 @default.
• W1974089713 date "2014-03-25" @default.
• W1974089713 modified "2023-10-14" @default.
• W1974089713 title "Non-Thermal Atmospheric Pressure Plasma Inhibits Thyroid Papillary Cancer Cell Invasion via Cytoskeletal Modulation, Altered MMP-2/-9/uPA Activity" @default.
• W1974089713 cites W1969342647 @default.
• W1974089713 cites W1969447729 @default.
• W1974089713 cites W1978133924 @default.
• W1974089713 cites W2006145157 @default.
• W1974089713 cites W2014007705 @default.
• W1974089713 cites W2021884192 @default.
• W1974089713 cites W2028627377 @default.
• W1974089713 cites W2031994938 @default.
• W1974089713 cites W2038314223 @default.
• W1974089713 cites W2039229559 @default.
• W1974089713 cites W2048117957 @default.
• W1974089713 cites W2050238137 @default.
• W1974089713 cites W2051284311 @default.
• W1974089713 cites W2059373592 @default.
• W1974089713 cites W2062974898 @default.
• W1974089713 cites W2063149223 @default.
• W1974089713 cites W2068328283 @default.
• W1974089713 cites W2068652698 @default.
• W1974089713 cites W2068768716 @default.
• W1974089713 cites W2083712459 @default.
• W1974089713 cites W2088032801 @default.
• W1974089713 cites W2095130439 @default.
• W1974089713 cites W2101125498 @default.
• W1974089713 cites W2104584000 @default.
• W1974089713 cites W2106404417 @default.
• W1974089713 cites W2106827909 @default.
• W1974089713 cites W2107164894 @default.
• W1974089713 cites W2118135400 @default.
• W1974089713 cites W2129077270 @default.
• W1974089713 cites W2130838656 @default.
• W1974089713 cites W2131867674 @default.
• W1974089713 cites W2151659223 @default.
• W1974089713 cites W2152054207 @default.
• W1974089713 cites W2153582542 @default.
• W1974089713 cites W2157201202 @default.
• W1974089713 cites W2162300265 @default.
• W1974089713 cites W2168159338 @default.
• W1974089713 cites W2171062412 @default.
• W1974089713 cites W4213174658 @default.
• W1974089713 doi "https://doi.org/10.1371/journal.pone.0092198" @default.
• W1974089713 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3965425" @default.
• W1974089713 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/24667444" @default.
• W1974089713 hasPublicationYear "2014" @default.
• W1974089713 type Work @default.
• W1974089713 sameAs 1974089713 @default.
• W1974089713 citedByCount "71" @default.
• W1974089713 countsByYear W19740897132014 @default.
• W1974089713 countsByYear W19740897132015 @default.
• W1974089713 countsByYear W19740897132016 @default.
• W1974089713 countsByYear W19740897132017 @default.
• W1974089713 countsByYear W19740897132018 @default.
• W1974089713 countsByYear W19740897132019 @default.
• W1974089713 countsByYear W19740897132020 @default.
• W1974089713 countsByYear W19740897132021 @default.
• W1974089713 countsByYear W19740897132022 @default.
• W1974089713 countsByYear W19740897132023 @default.
• W1974089713 crossrefType "journal-article" @default.
• W1974089713 hasAuthorship W1974089713A5004170846 @default.
• W1974089713 hasAuthorship W1974089713A5024610841 @default.
• W1974089713 hasAuthorship W1974089713A5025705059 @default.
• W1974089713 hasAuthorship W1974089713A5037196214 @default.
• W1974089713 hasAuthorship W1974089713A5038172025 @default.
• W1974089713 hasAuthorship W1974089713A5063870533 @default.
• W1974089713 hasAuthorship W1974089713A5066098737 @default.
• W1974089713 hasAuthorship W1974089713A5077609217 @default.
• W1974089713 hasAuthorship W1974089713A5081449876 @default.
• W1974089713 hasAuthorship W1974089713A5083028758 @default.
• W1974089713 hasBestOaLocation W19740897131 @default.
• W1974089713 hasConcept C108636557 @default.
• W1974089713 hasConcept C109523444 @default.
• W1974089713 hasConcept C116581196 @default.
• W1974089713 hasConcept C121608353 @default.
• W1974089713 hasConcept C126322002 @default.
• W1974089713 hasConcept C137738243 @default.
• W1974089713 hasConcept C142669718 @default.
• W1974089713 hasConcept C142724271 @default.
• W1974089713 hasConcept C1491633281 @default.
• W1974089713 hasConcept C185592680 @default.
• W1974089713 hasConcept C2779013556 @default.
• W1974089713 hasConcept C2779761222 @default.
• W1974089713 hasConcept C35866371 @default.
• W1974089713 hasConcept C502942594 @default.
• W1974089713 hasConcept C55493867 @default.

• next