Matches in SemOpenAlex for { <https://semopenalex.org/work/W1974090265> ?p ?o ?g. }
- W1974090265 endingPage "185" @default.
- W1974090265 startingPage "175" @default.
- W1974090265 abstract "5-Hydroxytryptamine (5-HT) has been reported to modulate analgesia produced by opioids or electrical stimulation of the periaqueductal gray (PAG). 5-HT increases K+ conductance and inhibits the firing activity of the PAG neurons. We examined the electrophysiological and pharmacological characteristics of the K+ current involved in 5-HT-induced hyperpolarization of dissociated rat PAG neurons. Among the neurons tested, 5-HT activated inward K+ currents in 30–40%, whilst the remaining 60–70% did not respond to 5-HT. 5-HT activated an inwardly rectifying K+ current (I5-HT) in a concentration- and voltage-dependent manner. I5-HT was mimicked by a 5-HT1A receptor selective agonist, 8-OH-DPAT, and was reversibly blocked by a 5-HT1A receptor antagonist, piperazine maleate, but not by a 5-HT2 receptor antagonist, ketanserin. I5-HT was sensitive to K+ channel blockers such as quinine and Ba2+, but insensitive to 4-aminopyridine, Cs+ and tetraethylammonium. I5-HT was inhibited by GDPβs and was irreversibly activated by GTPγs. I5-HT was significantly suppressed by N-ethylmaleimide and pertussis toxin, but not by cholera toxin. Second messenger modulators such as staurosporin, forskolin, and phorbol-12-myristate-13-acetate did not alter I5-HT. The present study indicates that 5-HT-induced hyperpolarization of the PAG neurons results from activation of the pertussis toxin-sensitive G-protein-coupled inwardly rectifying K+ currents through 5-HT1A receptors." @default.
- W1974090265 created "2016-06-24" @default.
- W1974090265 creator A5062520797 @default.
- W1974090265 creator A5065117837 @default.
- W1974090265 creator A5068683121 @default.
- W1974090265 creator A5071433233 @default.
- W1974090265 date "2001-08-01" @default.
- W1974090265 modified "2023-10-11" @default.
- W1974090265 title "5-HT1A receptor-mediated activation of G-protein-gated inwardly rectifying K+ current in rat periaqueductal gray neurons" @default.
- W1974090265 cites W1492607105 @default.
- W1974090265 cites W1496211185 @default.
- W1974090265 cites W1519977525 @default.
- W1974090265 cites W1553532993 @default.
- W1974090265 cites W1565287219 @default.
- W1974090265 cites W1582905488 @default.
- W1974090265 cites W1617530841 @default.
- W1974090265 cites W1973671944 @default.
- W1974090265 cites W1981274437 @default.
- W1974090265 cites W1984746596 @default.
- W1974090265 cites W1989008205 @default.
- W1974090265 cites W1989436490 @default.
- W1974090265 cites W1989790870 @default.
- W1974090265 cites W1995489992 @default.
- W1974090265 cites W1997984286 @default.
- W1974090265 cites W2003723039 @default.
- W1974090265 cites W2009667219 @default.
- W1974090265 cites W2016983964 @default.
- W1974090265 cites W2024285800 @default.
- W1974090265 cites W2024568818 @default.
- W1974090265 cites W2025267797 @default.
- W1974090265 cites W2028360988 @default.
- W1974090265 cites W2040267189 @default.
- W1974090265 cites W2046281644 @default.
- W1974090265 cites W2047277297 @default.
- W1974090265 cites W2056145022 @default.
- W1974090265 cites W2059372946 @default.
- W1974090265 cites W2059818152 @default.
- W1974090265 cites W2065570092 @default.
- W1974090265 cites W2068095120 @default.
- W1974090265 cites W2075434858 @default.
- W1974090265 cites W2091061257 @default.
- W1974090265 cites W2095858175 @default.
- W1974090265 cites W2135543795 @default.
- W1974090265 cites W2138512124 @default.
- W1974090265 cites W2147476070 @default.
- W1974090265 cites W2149878506 @default.
- W1974090265 cites W2167049110 @default.
- W1974090265 cites W2419532483 @default.
- W1974090265 doi "https://doi.org/10.1016/s0028-3908(01)00062-4" @default.
- W1974090265 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/11489454" @default.
- W1974090265 hasPublicationYear "2001" @default.
- W1974090265 type Work @default.
- W1974090265 sameAs 1974090265 @default.
- W1974090265 citedByCount "42" @default.
- W1974090265 countsByYear W19740902652012 @default.
- W1974090265 countsByYear W19740902652013 @default.
- W1974090265 countsByYear W19740902652015 @default.
- W1974090265 countsByYear W19740902652016 @default.
- W1974090265 countsByYear W19740902652017 @default.
- W1974090265 countsByYear W19740902652018 @default.
- W1974090265 countsByYear W19740902652019 @default.
- W1974090265 countsByYear W19740902652020 @default.
- W1974090265 countsByYear W19740902652021 @default.
- W1974090265 crossrefType "journal-article" @default.
- W1974090265 hasAuthorship W1974090265A5062520797 @default.
- W1974090265 hasAuthorship W1974090265A5065117837 @default.
- W1974090265 hasAuthorship W1974090265A5068683121 @default.
- W1974090265 hasAuthorship W1974090265A5071433233 @default.
- W1974090265 hasConcept C12554922 @default.
- W1974090265 hasConcept C126322002 @default.
- W1974090265 hasConcept C131453863 @default.
- W1974090265 hasConcept C134018914 @default.
- W1974090265 hasConcept C142652207 @default.
- W1974090265 hasConcept C170493617 @default.
- W1974090265 hasConcept C178790620 @default.
- W1974090265 hasConcept C185592680 @default.
- W1974090265 hasConcept C26702167 @default.
- W1974090265 hasConcept C2775864247 @default.
- W1974090265 hasConcept C2777785214 @default.
- W1974090265 hasConcept C2778938600 @default.
- W1974090265 hasConcept C2779276759 @default.
- W1974090265 hasConcept C2781069035 @default.
- W1974090265 hasConcept C2781093953 @default.
- W1974090265 hasConcept C2781295685 @default.
- W1974090265 hasConcept C49773422 @default.
- W1974090265 hasConcept C517785266 @default.
- W1974090265 hasConcept C529278444 @default.
- W1974090265 hasConcept C53910766 @default.
- W1974090265 hasConcept C552161191 @default.
- W1974090265 hasConcept C55493867 @default.
- W1974090265 hasConcept C66974803 @default.
- W1974090265 hasConcept C71240020 @default.
- W1974090265 hasConcept C71924100 @default.
- W1974090265 hasConcept C80631254 @default.
- W1974090265 hasConcept C86803240 @default.
- W1974090265 hasConceptScore W1974090265C12554922 @default.
- W1974090265 hasConceptScore W1974090265C126322002 @default.
- W1974090265 hasConceptScore W1974090265C131453863 @default.