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• W1974095433 abstract "RNA 2',3'-cyclic phosphate ends play important roles in RNA metabolism as substrates for RNA ligases during tRNA restriction-repair and tRNA splicing. Diverse bacteria from multiple phyla encode a two-component RNA repair cassette, comprising Pnkp (polynucleotide kinase-phosphatase-ligase) and Hen1 (RNA 3'-terminal ribose 2'-O-methyltransferase), that heals and then seals broken tRNAs with 2',3'-cyclic phosphate and 5'-OH ends. The Pnkp-Hen1 repair operon is absent in the majority of bacterial species, thereby raising the prospect that other RNA repair systems might be extant. A candidate component is RNA 3'-phosphate cyclase, a widely distributed enzyme that transforms RNA 3'-monophosphate termini into 2',3'-cyclic phosphates but cannot seal the ends it produces. Escherichia coli RNA cyclase (RtcA) is encoded in a σ(54)-regulated operon with RtcB, a protein of unknown function. Taking a cue from Pnkp-Hen1, we purified E. coli RtcB and tested it for RNA ligase activity. We report that RtcB per se seals broken tRNA-like stem-loop structures with 2',3'-cyclic phosphate and 5'-OH ends to form a splice junction with a 2'-OH, 3',5'-phosphodiester. We speculate that: (i) RtcB might afford bacteria a means to recover from stress-induced RNA damage; and (ii) RtcB homologs might catalyze tRNA repair or splicing reactions in archaea and eukarya." @default.
• W1974095433 created "2016-06-24" @default.
• W1974095433 creator A5014112082 @default.
• W1974095433 creator A5042390766 @default.
• W1974095433 date "2011-03-01" @default.
• W1974095433 modified "2023-09-28" @default.
• W1974095433 title "RtcB Is the RNA Ligase Component of an Escherichia coli RNA Repair Operon" @default.
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• W1974095433 doi "https://doi.org/10.1074/jbc.c111.219022" @default.
• W1974095433 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3048659" @default.
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