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- W1974098368 abstract "Sandler AD, Sutton KA, DeWeese J, et al. Lack of benefit of a single dose of synthetic human secretin in the treatment of autism and pervasive developmental disorder. N Engl J Med1999 Dec 9; 341 : 1801 –6. [OpenUrl][1][CrossRef][2][PubMed][3][Web of Science][4] QUESTION: In children with autistic disorders, is synthetic human secretin effective for improving symptoms and communication skills? Randomised {allocation concealed*}†, blinded (patients, clinicians, outcome assessors),* placebo controlled trial with 4 weeks of follow up. A university in Chapel Hill, North Carolina, USA. 60 children who were 3–14 years of age (mean age 8 y) and had a previous diagnosis of autism were screened by using the DSM-IV , the Childhood Autism Rating Scale, and the Autism Behavior Checklist (ABC). 40 children met criteria for autism, and 20 met criteria for another pervasive developmental disorder. Exclusion criteria were previous … [1]: {openurl}?query=rft.jtitle%253DNew%2BEngland%2BJournal%2Bof%2BMedicine%26rft.stitle%253DNEJM%26rft.aulast%253DSandler%26rft.auinit1%253DA.%2BD.%26rft.volume%253D341%26rft.issue%253D24%26rft.spage%253D1801%26rft.epage%253D1806%26rft.atitle%253DLack%2Bof%2BBenefit%2Bof%2Ba%2BSingle%2BDose%2Bof%2BSynthetic%2BHuman%2BSecretin%2Bin%2Bthe%2BTreatment%2Bof%2BAutism%2Band%2BPervasive%2BDevelopmental%2BDisorder%26rft_id%253Dinfo%253Adoi%252F10.1056%252FNEJM199912093412404%26rft_id%253Dinfo%253Apmid%252F10588965%26rft.genre%253Darticle%26rft_val_fmt%253Dinfo%253Aofi%252Ffmt%253Akev%253Amtx%253Ajournal%26ctx_ver%253DZ39.88-2004%26url_ver%253DZ39.88-2004%26url_ctx_fmt%253Dinfo%253Aofi%252Ffmt%253Akev%253Amtx%253Actx [2]: /lookup/external-ref?access_num=10.1056/NEJM199912093412404&link_type=DOI [3]: /lookup/external-ref?access_num=10588965&link_type=MED&atom=%2Febmental%2F3%2F2%2F52.atom [4]: /lookup/external-ref?access_num=000084074000004&link_type=ISI" @default.
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- W1974098368 date "2000-05-01" @default.
- W1974098368 modified "2023-09-27" @default.
- W1974098368 title "Synthetic human secretin did not improve symptoms or communication skills in children with autistic disorders" @default.
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- W1974098368 doi "https://doi.org/10.1136/ebmh.3.2.52" @default.
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