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- W1974102627 abstract "□ The synthesis and the spectroscopic characterization of a new potential drug for urinary incontinence, adosupine, is described. Adosupine and its potential synthesis impurities were analyzed by a new HPLC method that was developed with a C18 reversed-phase column. The analysis was made under isocratic conditions, with a mobile phase of acetonitrile:water (15:85, v/v). Resolution of all synthesis Impurities was allowed. The method was also applied to stability studies of adosupine in solid state and in solution under different conditions. With the conditions used, only one degradation product was shown by HPLC analysis; it was isolated, characterized, and Identified as the hydrolysis product of the lactam ring present In the adosupine structure. □ The synthesis and the spectroscopic characterization of a new potential drug for urinary incontinence, adosupine, is described. Adosupine and its potential synthesis impurities were analyzed by a new HPLC method that was developed with a C18 reversed-phase column. The analysis was made under isocratic conditions, with a mobile phase of acetonitrile:water (15:85, v/v). Resolution of all synthesis Impurities was allowed. The method was also applied to stability studies of adosupine in solid state and in solution under different conditions. With the conditions used, only one degradation product was shown by HPLC analysis; it was isolated, characterized, and Identified as the hydrolysis product of the lactam ring present In the adosupine structure." @default.
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- W1974102627 date "1994-02-01" @default.
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- W1974102627 title "Synthesis, Characterization, and Analytical Studies of Adosupine, a Potential New Drug for Urinary Incontinence" @default.
- W1974102627 cites W2010528272 @default.
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- W1974102627 doi "https://doi.org/10.1002/jps.2600830206" @default.
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