FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1974107274> ?p ?o ?g. }

• W1974107274 endingPage "108" @default.
• W1974107274 startingPage "96" @default.
• W1974107274 abstract "Abstract We reported previously that BDNF induced glutamate release was dependent on intracellular Ca 2+ but not extracellular Ca 2+ in cerebellar neurons (Numakawa et al., 1999 ). It was revealed that the release was through a non‐exocytotic pathway (Takei et al., 1998 ; Numakawa et al., 1999 ). In the present study, we monitored the dynamics of intracellular Ca 2+ and Na + in cerebellar neurons, and investigated the possibility of reverse transport of glutamate mediated by BDNF. As reported, BDNF increased the intracellular Ca 2+ level. We found that the Ca 2+ increase induced by BDNF was completely blocked by xestospongin C, an IP 3 receptor antagonist, and U‐73122, a PLC‐γ inhibitor. Xestospongin C and U‐73122 also blocked the BDNF‐dependent glutamate release, suggesting that the BDNF‐induced transient increase of Ca 2+ through the activation of the PLC‐γ/ IP 3 pathway was essential for the glutamate release. We found that BDNF induced a Na + influx. This was blocked by treatment with TTX. U‐73122 and xestospongin C blocked the BDNF‐induced Na + influx, suggesting that the Na + influx required the BDNF‐induced Ca 2+ increase. Next, we examined the possibility that a co‐transporter of Na + and glutamate was involved in the BDNF‐induced glutamate release. BDNF‐induced glutamate release was blocked by L‐trans‐pyrollidine‐2,4‐dicalboxylic acid (t‐PDC), a glutamate transporter inhibitor, whereas neither the 4‐aminopyridine (4AP)‐ nor high potassium (HK + )‐induced release was blocked by t‐PDC. In addition, DL‐threo‐β‐benzyloxyaspartate (DL‐TBOA) also blocked the BDNF‐mediated glutamate release, suggesting that reverse transport of glutamate may be involved. All the results therefore suggest that Na + ‐dependent reverse transport contributes to BDNF‐mediated transmitter release through the PLC‐γ/IP 3 ‐mediated Ca 2+ signaling. J. Neurosci. Res. 66:96–108, 2001. © 2001 Wiley‐Liss, Inc." @default.
• W1974107274 created "2016-06-24" @default.
• W1974107274 creator A5005841735 @default.
• W1974107274 creator A5030455627 @default.
• W1974107274 creator A5043042138 @default.
• W1974107274 creator A5047809277 @default.
• W1974107274 creator A5065918021 @default.
• W1974107274 creator A5075384535 @default.
• W1974107274 creator A5087822481 @default.
• W1974107274 date "2001-09-26" @default.
• W1974107274 modified "2023-10-10" @default.
• W1974107274 title "Brain-derived neurotrophic factor triggers a rapid glutamate release through increase of intracellular Ca2+ and Na+ in cultured cerebellar neurons" @default.
• W1974107274 cites W1497671444 @default.
• W1974107274 cites W1530428799 @default.
• W1974107274 cites W1595049684 @default.
• W1974107274 cites W1625740378 @default.
• W1974107274 cites W1863572237 @default.
• W1974107274 cites W1897264013 @default.
• W1974107274 cites W1961530921 @default.
• W1974107274 cites W1967977725 @default.
• W1974107274 cites W1968399538 @default.
• W1974107274 cites W1969400861 @default.
• W1974107274 cites W1971263143 @default.
• W1974107274 cites W1972161610 @default.
• W1974107274 cites W1975421593 @default.
• W1974107274 cites W1979305117 @default.
• W1974107274 cites W1980155257 @default.
• W1974107274 cites W1983197885 @default.
• W1974107274 cites W1985912458 @default.
• W1974107274 cites W1989938166 @default.
• W1974107274 cites W1990383598 @default.
• W1974107274 cites W1991701465 @default.
• W1974107274 cites W2004273706 @default.
• W1974107274 cites W2010403667 @default.
• W1974107274 cites W2011965698 @default.
• W1974107274 cites W2018524477 @default.
• W1974107274 cites W2029184215 @default.
• W1974107274 cites W2029863311 @default.
• W1974107274 cites W2035371282 @default.
• W1974107274 cites W2036685092 @default.
• W1974107274 cites W2039202482 @default.
• W1974107274 cites W2047160088 @default.
• W1974107274 cites W2052794702 @default.
• W1974107274 cites W2054336759 @default.
• W1974107274 cites W2055265981 @default.
• W1974107274 cites W2062860475 @default.
• W1974107274 cites W2063332150 @default.
• W1974107274 cites W2065021869 @default.
• W1974107274 cites W2074698464 @default.
• W1974107274 cites W2078316783 @default.
• W1974107274 cites W2080102887 @default.
• W1974107274 cites W2088650980 @default.
• W1974107274 cites W2091758977 @default.
• W1974107274 cites W2094089753 @default.
• W1974107274 cites W2102204826 @default.
• W1974107274 cites W2102410706 @default.
• W1974107274 cites W2118153193 @default.
• W1974107274 cites W2153279852 @default.
• W1974107274 cites W2155166279 @default.
• W1974107274 cites W2155760865 @default.
• W1974107274 cites W330009103 @default.
• W1974107274 cites W2070266619 @default.
• W1974107274 doi "https://doi.org/10.1002/jnr.1201" @default.
• W1974107274 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/11599006" @default.
• W1974107274 hasPublicationYear "2001" @default.
• W1974107274 type Work @default.
• W1974107274 sameAs 1974107274 @default.
• W1974107274 citedByCount "55" @default.
• W1974107274 countsByYear W19741072742012 @default.
• W1974107274 countsByYear W19741072742013 @default.
• W1974107274 countsByYear W19741072742014 @default.
• W1974107274 countsByYear W19741072742015 @default.
• W1974107274 countsByYear W19741072742016 @default.
• W1974107274 countsByYear W19741072742018 @default.
• W1974107274 countsByYear W19741072742019 @default.
• W1974107274 countsByYear W19741072742021 @default.
• W1974107274 countsByYear W19741072742022 @default.
• W1974107274 countsByYear W19741072742023 @default.
• W1974107274 crossrefType "journal-article" @default.
• W1974107274 hasAuthorship W1974107274A5005841735 @default.
• W1974107274 hasAuthorship W1974107274A5030455627 @default.
• W1974107274 hasAuthorship W1974107274A5043042138 @default.
• W1974107274 hasAuthorship W1974107274A5047809277 @default.
• W1974107274 hasAuthorship W1974107274A5065918021 @default.
• W1974107274 hasAuthorship W1974107274A5075384535 @default.
• W1974107274 hasAuthorship W1974107274A5087822481 @default.
• W1974107274 hasConcept C12554922 @default.
• W1974107274 hasConcept C160539049 @default.
• W1974107274 hasConcept C170493617 @default.
• W1974107274 hasConcept C185592680 @default.
• W1974107274 hasConcept C2778790584 @default.
• W1974107274 hasConcept C49051014 @default.
• W1974107274 hasConcept C55493867 @default.
• W1974107274 hasConcept C61174792 @default.
• W1974107274 hasConcept C67018056 @default.
• W1974107274 hasConcept C79879829 @default.
• W1974107274 hasConcept C86803240 @default.
• W1974107274 hasConcept C95444343 @default.

• next