Matches in SemOpenAlex for { <https://semopenalex.org/work/W1974112821> ?p ?o ?g. }
Showing items 1 to 97 of
97
with 100 items per page.
- W1974112821 endingPage "PL113" @default.
- W1974112821 startingPage "PL107" @default.
- W1974112821 abstract "The hypothesis that μ-opioid agonists having low antinociceptive efficacy might be more susceptible to interference with G-protein coupling than μ-opioid agonists having higher antinocicep-tive efficacy was tested. Supraspinal antinociceptive efficacy for the three μ-opioid agonists morphine, [D-Ala2, NMePhe4, Gly5-ol]-enkephalin (DAMGO) and sufentanil in the mouse 55 °C warm-water tail-flick test was evaluated 18–24 h after intracerebroventricular (i.c.v.) administration of β-funaltrexamine (β-FNA). The β-FNA pretreatment (0.2–2.0 nmol) attenuated antinociception in the order morphine > DAMGO > sufentanil, consistent with previous reports of their relative antinociceptive efficacy. The association of efficacy with G-protein coupling was then assessed by determining sensitivity to i.c.v. (0.1–3.0 μg) pertussis toxin (PTX) or cholera toxin (CTX). The effect of PTX on equiantinociceptive doses was in the inverse order of agonist efficacy. CTX augmented sufentanil-induced antinociception. Morphine- and DAMGO-induced antinociception were unaffected by CTX. These data suggest that: (i) highly efficacious μ agonists (viz., sufentanil) couple more efficiently to PTX-sensitive inhibitory Gi-proteins than do agonists of lower efficacy (viz., morphine, DAMGO) and (ii) highly efficacious μ agonists have greater capacity to utilize CTX-sensitive stimulatory Gs-proteins than do μ-agonists with lower efficacy." @default.
- W1974112821 created "2016-06-24" @default.
- W1974112821 creator A5077593052 @default.
- W1974112821 creator A5080583451 @default.
- W1974112821 date "1997-01-01" @default.
- W1974112821 modified "2023-09-27" @default.
- W1974112821 title "An examination of the relationship between μ-opioid antinociceptive efficacy and G-protein coupling using pertussis and cholera toxins" @default.
- W1974112821 cites W1983119189 @default.
- W1974112821 cites W1986450527 @default.
- W1974112821 cites W1988681903 @default.
- W1974112821 cites W2002845499 @default.
- W1974112821 cites W2010292685 @default.
- W1974112821 cites W2025374159 @default.
- W1974112821 cites W2029582966 @default.
- W1974112821 cites W2036143670 @default.
- W1974112821 cites W2044427832 @default.
- W1974112821 cites W2050909827 @default.
- W1974112821 cites W2052191785 @default.
- W1974112821 cites W2058724065 @default.
- W1974112821 cites W2072241600 @default.
- W1974112821 cites W2073981715 @default.
- W1974112821 cites W2076798747 @default.
- W1974112821 cites W2092603478 @default.
- W1974112821 cites W2095014478 @default.
- W1974112821 cites W2269570071 @default.
- W1974112821 cites W2894081247 @default.
- W1974112821 doi "https://doi.org/10.1016/s0024-3205(96)00684-4" @default.
- W1974112821 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/9042382" @default.
- W1974112821 hasPublicationYear "1997" @default.
- W1974112821 type Work @default.
- W1974112821 sameAs 1974112821 @default.
- W1974112821 citedByCount "19" @default.
- W1974112821 countsByYear W19741128212013 @default.
- W1974112821 countsByYear W19741128212014 @default.
- W1974112821 countsByYear W19741128212016 @default.
- W1974112821 countsByYear W19741128212018 @default.
- W1974112821 countsByYear W19741128212019 @default.
- W1974112821 countsByYear W19741128212020 @default.
- W1974112821 crossrefType "journal-article" @default.
- W1974112821 hasAuthorship W1974112821A5077593052 @default.
- W1974112821 hasAuthorship W1974112821A5080583451 @default.
- W1974112821 hasConcept C126322002 @default.
- W1974112821 hasConcept C15490471 @default.
- W1974112821 hasConcept C170493617 @default.
- W1974112821 hasConcept C185592680 @default.
- W1974112821 hasConcept C2776401185 @default.
- W1974112821 hasConcept C2777006276 @default.
- W1974112821 hasConcept C2777019824 @default.
- W1974112821 hasConcept C2777389121 @default.
- W1974112821 hasConcept C2777803847 @default.
- W1974112821 hasConcept C2778938600 @default.
- W1974112821 hasConcept C2781063702 @default.
- W1974112821 hasConcept C49773422 @default.
- W1974112821 hasConcept C55493867 @default.
- W1974112821 hasConcept C71924100 @default.
- W1974112821 hasConcept C80631254 @default.
- W1974112821 hasConcept C89951826 @default.
- W1974112821 hasConcept C98274493 @default.
- W1974112821 hasConceptScore W1974112821C126322002 @default.
- W1974112821 hasConceptScore W1974112821C15490471 @default.
- W1974112821 hasConceptScore W1974112821C170493617 @default.
- W1974112821 hasConceptScore W1974112821C185592680 @default.
- W1974112821 hasConceptScore W1974112821C2776401185 @default.
- W1974112821 hasConceptScore W1974112821C2777006276 @default.
- W1974112821 hasConceptScore W1974112821C2777019824 @default.
- W1974112821 hasConceptScore W1974112821C2777389121 @default.
- W1974112821 hasConceptScore W1974112821C2777803847 @default.
- W1974112821 hasConceptScore W1974112821C2778938600 @default.
- W1974112821 hasConceptScore W1974112821C2781063702 @default.
- W1974112821 hasConceptScore W1974112821C49773422 @default.
- W1974112821 hasConceptScore W1974112821C55493867 @default.
- W1974112821 hasConceptScore W1974112821C71924100 @default.
- W1974112821 hasConceptScore W1974112821C80631254 @default.
- W1974112821 hasConceptScore W1974112821C89951826 @default.
- W1974112821 hasConceptScore W1974112821C98274493 @default.
- W1974112821 hasIssue "7" @default.
- W1974112821 hasLocation W19741128211 @default.
- W1974112821 hasLocation W19741128212 @default.
- W1974112821 hasOpenAccess W1974112821 @default.
- W1974112821 hasPrimaryLocation W19741128211 @default.
- W1974112821 hasRelatedWork W1966153991 @default.
- W1974112821 hasRelatedWork W1974112821 @default.
- W1974112821 hasRelatedWork W1994615753 @default.
- W1974112821 hasRelatedWork W2052191785 @default.
- W1974112821 hasRelatedWork W2055877187 @default.
- W1974112821 hasRelatedWork W2091827449 @default.
- W1974112821 hasRelatedWork W2110133277 @default.
- W1974112821 hasRelatedWork W3173023943 @default.
- W1974112821 hasRelatedWork W4206871862 @default.
- W1974112821 hasRelatedWork W4287435042 @default.
- W1974112821 hasVolume "60" @default.
- W1974112821 isParatext "false" @default.
- W1974112821 isRetracted "false" @default.
- W1974112821 magId "1974112821" @default.
- W1974112821 workType "article" @default.