FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1974119333> ?p ?o ?g. }

• W1974119333 endingPage "6090" @default.
• W1974119333 startingPage "6090" @default.
• W1974119333 abstract "The crystallization of norfloxacin, an antibacterial fluoroquinolone compound, with different benzenedicarboxylic acids yields five novel pharmaceutical salts via molecular recognition. X-ray single-crystal diffraction analyses reveal that these pharmaceutical agents present uniform charge-assistant hydrogen-bonding networks, which are in 1 : 1 stoichiometry of norfloxacin and dicarboxylate therein (with the exception of that with terephthalate). Unsubstituted benzenedicarboxylates (phthalate in 1, isophthalate in 2, and terephthalate in 3, respectively) are likely to crystallize with norfloxacin without lattice solvents, while the substituted isophthalate moieties (2-aminoisophthalate in 4 and 5-aminoisophthalate in 5) tend to form supramolecular adducts with the inclusion of water. Aromatic stacking interactions are present in all these structures, occurring between the fluoroquinolone and carboxylate phenyl rings (in 1–4) as well as between the fluoroquinolone planes (in 5). Thermal stability and solubility of all crystalline binary adducts have been determined. The effect of carboxylate counterions, substituents, and hydration states on the solubility and dissolution profile of drug salts 1–5 are investigated in pure water and 0.1 M HCl. After the formation of salts, the solubility increases at near neutral pH in almost all cases (except 3), but the order is changed in acidic medium. Phthalic acid shows evidence of a good candidate to enhance the solubility of fluoroquinolone drugs for the solubility of 1 is approximately 39 times as large as that of norfloxacin in pure water and also larger than that of norfloxacin in acidic system. For the isophthalates series, 2 has very poor solubility in 0.1 M HCl (only 0.06 times as that of Nf), while amino substituted isophthalates result in the enhancement of the solubility. Remarkably, crystal packing analyses of these pharmaceutical salts allow a possible correlation between the H-bonding prototypes and the solubility to be established." @default.
• W1974119333 created "2016-06-24" @default.
• W1974119333 creator A5004710880 @default.
• W1974119333 creator A5009094213 @default.
• W1974119333 creator A5012571820 @default.
• W1974119333 creator A5014277040 @default.
• W1974119333 creator A5028541832 @default.
• W1974119333 creator A5034233393 @default.
• W1974119333 creator A5035445599 @default.
• W1974119333 creator A5038836690 @default.
• W1974119333 creator A5058661530 @default.
• W1974119333 creator A5083862643 @default.
• W1974119333 date "2013-01-01" @default.
• W1974119333 modified "2023-10-14" @default.
• W1974119333 title "Norfloxacin salts with benzenedicarboxylic acids: charge-assisted hydrogen-bonding recognition and solubility regulation" @default.
• W1974119333 cites W1965625101 @default.
• W1974119333 cites W1970288803 @default.
• W1974119333 cites W1972646318 @default.
• W1974119333 cites W1975566347 @default.
• W1974119333 cites W1978873740 @default.
• W1974119333 cites W1981353105 @default.
• W1974119333 cites W1982315739 @default.
• W1974119333 cites W1998920258 @default.
• W1974119333 cites W2007068681 @default.
• W1974119333 cites W2007861483 @default.
• W1974119333 cites W2008486371 @default.
• W1974119333 cites W2011134011 @default.
• W1974119333 cites W2013027128 @default.
• W1974119333 cites W2020722862 @default.
• W1974119333 cites W2025243884 @default.
• W1974119333 cites W2030081834 @default.
• W1974119333 cites W2043754555 @default.
• W1974119333 cites W2059910175 @default.
• W1974119333 cites W2060007358 @default.
• W1974119333 cites W2074411126 @default.
• W1974119333 cites W2082106064 @default.
• W1974119333 cites W2082469760 @default.
• W1974119333 cites W2144646251 @default.
• W1974119333 cites W2150644333 @default.
• W1974119333 cites W2163742089 @default.
• W1974119333 cites W2166689829 @default.
• W1974119333 cites W4247665233 @default.
• W1974119333 doi "https://doi.org/10.1039/c3ce40567b" @default.
• W1974119333 hasPublicationYear "2013" @default.
• W1974119333 type Work @default.
• W1974119333 sameAs 1974119333 @default.
• W1974119333 citedByCount "33" @default.
• W1974119333 countsByYear W19741193332014 @default.
• W1974119333 countsByYear W19741193332015 @default.
• W1974119333 countsByYear W19741193332016 @default.
• W1974119333 countsByYear W19741193332017 @default.
• W1974119333 countsByYear W19741193332018 @default.
• W1974119333 countsByYear W19741193332019 @default.
• W1974119333 countsByYear W19741193332020 @default.
• W1974119333 countsByYear W19741193332021 @default.
• W1974119333 countsByYear W19741193332022 @default.
• W1974119333 countsByYear W19741193332023 @default.
• W1974119333 crossrefType "journal-article" @default.
• W1974119333 hasAuthorship W1974119333A5004710880 @default.
• W1974119333 hasAuthorship W1974119333A5009094213 @default.
• W1974119333 hasAuthorship W1974119333A5012571820 @default.
• W1974119333 hasAuthorship W1974119333A5014277040 @default.
• W1974119333 hasAuthorship W1974119333A5028541832 @default.
• W1974119333 hasAuthorship W1974119333A5034233393 @default.
• W1974119333 hasAuthorship W1974119333A5035445599 @default.
• W1974119333 hasAuthorship W1974119333A5038836690 @default.
• W1974119333 hasAuthorship W1974119333A5058661530 @default.
• W1974119333 hasAuthorship W1974119333A5083862643 @default.
• W1974119333 hasConcept C100687433 @default.
• W1974119333 hasConcept C112887158 @default.
• W1974119333 hasConcept C155574463 @default.
• W1974119333 hasConcept C178790620 @default.
• W1974119333 hasConcept C179104552 @default.
• W1974119333 hasConcept C185592680 @default.
• W1974119333 hasConcept C203036418 @default.
• W1974119333 hasConcept C2778074193 @default.
• W1974119333 hasConcept C2778512257 @default.
• W1974119333 hasConcept C2778746504 @default.
• W1974119333 hasConcept C32909587 @default.
• W1974119333 hasConcept C501593827 @default.
• W1974119333 hasConcept C55493867 @default.
• W1974119333 hasConcept C88380143 @default.
• W1974119333 hasConceptScore W1974119333C100687433 @default.
• W1974119333 hasConceptScore W1974119333C112887158 @default.
• W1974119333 hasConceptScore W1974119333C155574463 @default.
• W1974119333 hasConceptScore W1974119333C178790620 @default.
• W1974119333 hasConceptScore W1974119333C179104552 @default.
• W1974119333 hasConceptScore W1974119333C185592680 @default.
• W1974119333 hasConceptScore W1974119333C203036418 @default.
• W1974119333 hasConceptScore W1974119333C2778074193 @default.
• W1974119333 hasConceptScore W1974119333C2778512257 @default.
• W1974119333 hasConceptScore W1974119333C2778746504 @default.
• W1974119333 hasConceptScore W1974119333C32909587 @default.
• W1974119333 hasConceptScore W1974119333C501593827 @default.
• W1974119333 hasConceptScore W1974119333C55493867 @default.
• W1974119333 hasConceptScore W1974119333C88380143 @default.
• W1974119333 hasIssue "30" @default.
• W1974119333 hasLocation W19741193331 @default.

• next