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• W1974120587 abstract "A novel class of potent aminopeptidase N inhibitors with 3-amino-cyclic-imide scaffold is described. The preliminary biological test revealed that all the compounds displayed high specific inhibitory activity against aminopeptidase N compared with previous work because of the existence of free amino group. Compounds containing hydroxamate group are more potent than carboxyl and ester derivatives. Compound 13f potentially inhibited APN activity with IC(50) value of 1.8 microM and displayed specific activity profiles in cells assay and in vivo anti-metastasis assay." @default.
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• W1974120587 date "2010-04-01" @default.
• W1974120587 modified "2023-10-15" @default.
• W1974120587 title "Novel cyclic-imide peptidomimetics as aminopeptidase N inhibitors. Structure-based design, chemistry and activity evaluation. II" @default.
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• W1974120587 doi "https://doi.org/10.1016/j.ejmech.2009.12.071" @default.
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