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• W1974156727 abstract "Research suggests that regular opioid use for chronic pain is associated with poorer quality of life, maladaptive coping strategies, greater physical disability and pain severity, and more depressive symptoms. The purpose of this study was to examine the relationship between opioid use and depression on pain severity and physical, social, and emotional functioning. Participants were 449 patients (mean age = 45.9; 78.6% female; 95.3% Caucasian) with chronic non-cancer pain admitted to a multidisciplinary pain rehabilitation program. Prior to admission, patients were administered self-report inventories assessing opioid use, depression (Center for Epidemiological Studies- Depression; CES-D), pain severity, pain catastrophizing (Pain Catastrophizing Scale; PCS), pain interference, activity level and perceived control (Multidimensional Pain Inventory), and physical, social, and emotional functioning (SF-36 Health Survey). Results indicated that opioid users reported significantly more depressive symptoms than patients not on opioids, and that over half of patients on opioids were clinically depressed (CES-D ≤ 27). Both opioid use and depression were associated with greater pain severity; however, only depression was associated with greater pain interference, less perceived control, decreased activity levels, and impairment in physical, social, and emotional functioning. Although opioid use was associated with poorer perceived health and greater pain catastrophizing, follow up analyses indicated that depression was a significant moderator of this relationship. Thus, depression appears to play a more significant role in physical, social, and emotional functioning than opioid use. Although the nature of the relationship between opioid use and depression is unclear, one possibility is that patients with co-morbid chronic pain and depression report significant distress, increased pain severity, and decreased functioning, and therefore are more likely to receive opioid medication. Given the impact of depression on functioning, a thorough assessment of mood symptoms should be conducted when considering opioid therapy for chronic pain. Research suggests that regular opioid use for chronic pain is associated with poorer quality of life, maladaptive coping strategies, greater physical disability and pain severity, and more depressive symptoms. The purpose of this study was to examine the relationship between opioid use and depression on pain severity and physical, social, and emotional functioning. Participants were 449 patients (mean age = 45.9; 78.6% female; 95.3% Caucasian) with chronic non-cancer pain admitted to a multidisciplinary pain rehabilitation program. Prior to admission, patients were administered self-report inventories assessing opioid use, depression (Center for Epidemiological Studies- Depression; CES-D), pain severity, pain catastrophizing (Pain Catastrophizing Scale; PCS), pain interference, activity level and perceived control (Multidimensional Pain Inventory), and physical, social, and emotional functioning (SF-36 Health Survey). Results indicated that opioid users reported significantly more depressive symptoms than patients not on opioids, and that over half of patients on opioids were clinically depressed (CES-D ≤ 27). Both opioid use and depression were associated with greater pain severity; however, only depression was associated with greater pain interference, less perceived control, decreased activity levels, and impairment in physical, social, and emotional functioning. Although opioid use was associated with poorer perceived health and greater pain catastrophizing, follow up analyses indicated that depression was a significant moderator of this relationship. Thus, depression appears to play a more significant role in physical, social, and emotional functioning than opioid use. Although the nature of the relationship between opioid use and depression is unclear, one possibility is that patients with co-morbid chronic pain and depression report significant distress, increased pain severity, and decreased functioning, and therefore are more likely to receive opioid medication. Given the impact of depression on functioning, a thorough assessment of mood symptoms should be conducted when considering opioid therapy for chronic pain." @default.
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• W1974156727 date "2009-04-01" @default.
• W1974156727 modified "2023-09-26" @default.
• W1974156727 title "Depression, more than opioid use, is associated with impaired physical, social, and emotional functioning in chronic non-cancer pain" @default.
• W1974156727 doi "https://doi.org/10.1016/j.jpain.2009.01.243" @default.
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